Degradable metal patch and preparation method thereof

A metal patch and metal sheet technology, applied in the field of medical materials, can solve the problems of low strength, unable to provide effective support, limited application range, etc., achieve good strength and toughness, meet the needs of wound repair, and be less prone to inflammatory reactions.

Active Publication Date: 2021-05-28
苏州晶俊新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the strength of the patch is low and cannot provide effective support, so the range of application is limited
[0004] Therefore, the existing technology cannot meet and solve the above problems at the same time, and it is a meaningful work to develop a patch that is degradable in vivo, has good support performance and anti-adhesion

Method used

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  • Degradable metal patch and preparation method thereof
  • Degradable metal patch and preparation method thereof
  • Degradable metal patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Such as figure 1 Shown, according to the preparation method of degradable metal patch of the present invention, concrete steps are as follows:

[0038] S1, wire preparation

[0039] Specifically, for example, cast a magnesium alloy ingot with a composition of 2wt% Zn and the balance of Mg, and obtain magnesium alloy thick wire with a diameter of less than 1.5 mm through hot extrusion. The magnesium alloy thick wire is drawn and heat-treated many times to obtain two Magnesium alloy filaments of different diameters, wherein the first diameter is about 30 μm and the second diameter is about 50 μm. Wherein the drawing and heat treatment processes are wire drawing and heat treatment processes common in the art.

[0040] S2, wire pretreatment

[0041] The magnesium alloy filament obtained in step S1 is subjected to surface treatment, the surface treatment adopts micro-arc oxidation treatment, the termination voltage is 200V, and the temperature is 4°C.

[0042] S3, cuttin...

Embodiment 2

[0049] The preparation method of the degradable metal patch in this example, the specific steps are as follows:

[0050]S1. Hot extrusion of pure magnesium ingots to obtain pure magnesium thick wires with a diameter of 1.5 mm or less, and the pure magnesium thick wires are drawn and heat-treated in multiple passes to obtain pure magnesium filaments with diameters of 30 μm, 50 μm and 80 μm;

[0051] S2, subjecting the pure magnesium filaments obtained in step S1 to surface fluorination treatment at a temperature of 80° C. for 24 hours;

[0052] S3, cutting and dispersing the pure magnesium filaments obtained in step S2 with an aspect ratio of 100:1 to 1000:1, and uniformly mixing pure magnesium filaments of the same diameter;

[0053] S4. Put the 30 μm, 50 μm and 80 μm mixed magnesium alloy wire segments obtained in step S3 into cold pressing molds, and put them in amounts of 2.23g, 1.96g and 1.57g respectively, and press them into three kinds of pure magnesium sheets at room t...

Embodiment 3

[0059] The preparation method of the degradable metal patch in this example, the specific steps are as follows:

[0060] S1. Cast a zinc alloy ingot with a composition of 0.5wt% Mg and the balance of Zn, and obtain zinc alloy thick wire with a diameter of 1.5 mm or less by hot extrusion, and the zinc alloy thick wire is drawn and heat-treated through multiple passes to obtain Zinc alloy filaments with a diameter of 30 and 100 μm;

[0061] S2, subjecting the zinc alloy filament obtained in step S1 to surface anodic oxidation treatment, the current is 0.2A / dm 2 , the temperature is 18°C, and the time is 3min;

[0062] S3, cutting and dispersing the zinc alloy filament obtained in step S2 with an aspect ratio of 100:1 to 1000:1, and uniformly mixing zinc alloy filament segments with the same wire diameter;

[0063] S4. Put the 30 μm and 100 μm mixed zinc alloy wire segments obtained in step S3 into cold-pressing molds, the amount of which is respectively 4.4 g and 3.02 g, and p...

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Abstract

The invention provides a degradable metal patch and a preparation method thereof. The metal patch has a through hole structure with the porosity of 20%-50%. The preparation method of the degradable metal patch comprises the following steps: preparing a wire material; pre-treating the wire material; cutting the wire into sections, dispersing and mixing; performing cold pressing and preforming; and performing hot-press molding. The metal patch has excellent mechanical properties and biocompatibility, can protect damaged tissues, can convey substances such as nutrient substances and metabolites at the same time, and is gradually degraded along with a tissue healing process.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a medical degradable metal patch and a preparation method thereof. Background technique [0002] Mesh is widely used in craniofacial repair, pleura repair, skin repair, plastic surgery and other operations. The mesh is implanted in the wound site to fix and protect the lesion. Currently, traditional artificial patch materials are non-degradable materials such as polypropylene, polytetrafluoroethylene, polyester, and silica gel. For temporary wound closure repair, wrapping, support, etc., the patch will be permanently retained or secondary. surgical removal. This will greatly increase the risk of postoperative wound infection and foreign body reaction. At the same time, the strength of polymer materials is insufficient and the supporting capacity is poor, which is not conducive to providing a stable space for tissue repair. [0003] Facing the above problems, various degradable ...

Claims

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Application Information

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IPC IPC(8): A61L27/04A61L27/56A61L27/58A61L31/02A61L31/14B22F7/04
CPCA61L27/58A61L27/047A61L27/56B22F7/04A61L31/022A61L31/148A61L31/146
Inventor 白晶程兆俊邵怡
Owner 苏州晶俊新材料科技有限公司
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