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High-purity platelet continuous separation device

A separation device and platelet technology, which is applied in centrifuges, blood circulation processing, drug devices, etc., can solve the problems of low platelet collection rate and donor leukocyte loss, and achieves reduced possibility, stable product quality, and improved stratification. The effect of interface thickness

Pending Publication Date: 2021-05-25
龚小倩
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method will cause a large number of white blood cells and platelets of the donor to be stuck in the LRS centrifuge chamber and cannot be returned to the donor, which has the problems and defects of low platelet collection rate and large loss of donor white blood cells

Method used

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  • High-purity platelet continuous separation device
  • High-purity platelet continuous separation device
  • High-purity platelet continuous separation device

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0058] refer to figure 1 . In the first embodiment described below, a high-purity platelet continuous separation device includes: a tubular centrifuge 1 with a primary centrifuge area 2 and a secondary centrifuge area 3 and an elastic recoil device connected to the tubular centrifuge 1 The twisted tube bundle 10 is characterized in that: the primary centrifugal area 2 and the secondary centrifugal area 3 are isolated from each other, the anticoagulant whole blood vessel 14, the component blood vessel 15, and the red blood cell tube 16 are fixed and inserted into the primary centrifugal area 2 of the tubular centrifuge 1, and the anticoagulant The whole blood vessel 14 is provided with an anticoagulant whole blood inlet 4 in the primary centrifugal area 2, the component blood vessel 15 is provided with a component blood outlet 5 in the primary centrifugal area 2, and the red blood cell tube 16 is provided with a red blood cell outlet 6 in the primary centrifugal area 2. The co...

specific Embodiment approach 2

[0077] refer to Figure 12 . Preferably, since the possible residual impurity cells in the transfer tube 17 in the "process of removing impurity cells" in the specific embodiment 1 will be collected into the platelet collection bag 33 in the "process of collecting platelets", in order to obtain a higher platelet count than that of the program 1 Purity, a platelet collection port 9 is added in the secondary centrifugal area 3 to specifically collect platelets to obtain higher platelet purity. A continuous separation device for high-purity platelets, comprising: a tubular centrifuge 1 provided with a primary centrifuge zone 2 and a secondary centrifuge zone 3, and an elastic back-twist tube bundle 10 connected to the tube centrifuge 1, characterized in that: the primary centrifugation Area 2 and secondary centrifugation area 3 are isolated from each other, anticoagulated whole blood vessels 14, component blood vessels 15, and red blood cell tubes 16 are fixed and inserted into ...

specific Embodiment approach 3

[0088] refer to Figure 22 . In order to simplify the design of the external pipeline, reduce the number of external valves, reduce the use of three-way tubes and multi-way tubes to avoid damping the component blood passage, a transfer tube 2 17-1 can be added in the secondary centrifugal area 3, a The high-purity platelet continuous separation device includes: a tubular centrifuge 1 with a primary centrifugal area 2 and a secondary centrifugal area 3 and an elastic back-twist tube bundle 10 connected to the tubular centrifuge 1, characterized in that: the primary centrifugal area 2 Separated from the secondary centrifugal area 3, the anticoagulated whole blood vessel 14, the component blood vessel 15, and the red blood cell tube 16 are fixed and inserted into the primary centrifugal area 2 of the tubular centrifuge 1, and the anticoagulated whole blood vessel 14 is provided with an anticoagulant in the primary centrifugal area 2. Coagulated whole blood inlet 4, component blo...

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Abstract

The invention discloses a high-purity platelet continuous separation device. The separation device is high in platelet separation purity and concentration and collection efficiency. According to the technical scheme, the high-purity platelet continuous separation device comprises a tubular centrifuge provided with a primary centrifugal area and a secondary centrifugal area and an elastic back-twist tube bundle connected with the tubular centrifuge, and anticoagulant whole blood enters the primary centrifugal area for primary separation of platelets. The primarily separated platelets in the primary centrifugal area are transferred into the secondary centrifugal area to be purified and separated again, firstly impurity cells are extracted from the secondary centrifugal area and returned to the primary centrifugal area, and then the purified platelets are collected from the secondary centrifugal area.

Description

technical field [0001] The invention relates to a separation device mainly used for blood component separation, especially apheresis platelet and high-purity platelet. Background technique [0002] Component blood transfusion is a new technology of blood transfusion developed in recent decades with the progress of medical science and medical technology. The emergence and development of component blood transfusion is a milestone in the progress of modern blood transfusion. Component blood transfusion is obviously better than whole blood transfusion. Compared with whole blood transfusion, component blood transfusion has the following advantages: 1. High purity and good curative effect; 2. Safe transfusion and less side effects; 3. Good stability, easy to store and transport; 4. Comprehensive utilization, saving blood. [0003] Human blood is composed of red blood cells, white blood cells, platelets, plasma and other components. Component donation is to use a blood component ...

Claims

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Application Information

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IPC IPC(8): B04B5/04B04B5/10A61M1/38
CPCA61M1/38A61M2202/0413B04B5/0414B04B5/0442B04B5/10B04B2005/0435A61M2202/0021
Inventor 龚小倩
Owner 龚小倩
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