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Composite tissue adhesive as well as preparation method and application thereof

A composite tissue and adhesive technology, applied in applications, surgical adhesives, bandages, etc., can solve the problems of lack of mechanical strength and low tissue adhesion strength of adhesives, and achieve the effect of accelerating hydration expansion and drying speed. , the effect of high liquid absorption

Active Publication Date: 2021-05-14
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a composite tissue adhesive for the defects and deficiencies in the prior art, such as the low tissue adhesion strength of the tissue adhesive for wet wound repair and the lack of certain mechanical strength of the adhesive itself during use. agent

Method used

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  • Composite tissue adhesive as well as preparation method and application thereof
  • Composite tissue adhesive as well as preparation method and application thereof
  • Composite tissue adhesive as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0042] A composite tissue adhesive, the composite tissue adhesive comprises a three-dimensional porous matrix and an enhanced adhesion factor adsorbed on the surface of the matrix, the three-dimensional porous matrix is ​​composed of methacrylic anhydride gelatin and N-hydroxysuccinimide grafted polyamide. The composite hydrogel of acrylic acid is obtained by freeze-drying, and the adhesion-enhancing factor is polydopamine,

[0043] The composite tissue adhesive also includes polylysine and polyethyleneimine, and the carboxyl groups of polylysine and polyethyleneimine are linked to the succinimide end groups of the polyacrylic acid graft through peptide bonds.

[0044] The preparation method of composite tissue adhesive comprises the following steps:

[0045] S1: Mix methacrylic anhydride gelatin (the substitution rate of methacrylic acid is 75%) and polyacrylic acid, and perform NHS grafting on polyacrylic acid: weigh 20 mL of water into a beaker, add 2 g of polyacrylic acid,...

Embodiment 2

[0051] A composite tissue adhesive, the composite tissue adhesive comprises a three-dimensional porous matrix and an enhanced adhesion factor adsorbed on the surface of the matrix, the three-dimensional porous matrix is ​​composed of methacrylic anhydride gelatin and N-hydroxysuccinimide grafted polyamide. The composite hydrogel of acrylic acid is obtained by freeze-drying, and the adhesion-enhancing factor is polydopamine,

[0052] The composite tissue adhesive also includes polylysine, and the carboxyl group of polylysine is connected to the succinimide end group of the polyacrylic acid graft through a peptide bond.

[0053] The preparation method of composite tissue adhesive comprises the following steps:

[0054] S1: Mix methacrylic anhydride gelatin (the substitution rate of methacrylic acid is 95%) and polyacrylic acid, and perform NHS grafting on polyacrylic acid: Weigh 20 mL of water into a beaker, add 5 g of polyacrylic acid and 2 g of EDC successively , NHS 0.5g, me...

Embodiment 3

[0060] A composite tissue adhesive, the composite tissue adhesive comprises a three-dimensional porous matrix and an enhanced adhesion factor adsorbed on the surface of the matrix, the three-dimensional porous matrix is ​​composed of methacrylic anhydride gelatin and N-hydroxysuccinimide grafted polyamide. The composite hydrogel of acrylic acid is obtained by freeze-drying, and the adhesion-enhancing factor is polydopamine,

[0061] The composite tissue adhesive further comprises polyethyleneimine, and the carboxyl group of polyethyleneimide is connected to the succinimide end group of the polyacrylic acid graft through a peptide bond.

[0062] The preparation method of composite tissue adhesive comprises the following steps:

[0063] S1: Mix methacrylic anhydride gelatin (the substitution rate of methacrylic acid is 85%) and polyacrylic acid, and perform NHS grafting on polyacrylic acid: weigh 20 mL of water into a beaker, add 3 g of polyacrylic acid and 1 g of EDC successive...

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Abstract

The invention discloses a composite tissue adhesive as well as a preparation method and application thereof. The composite tissue adhesive comprises a three-dimensional porous matrix and an adhesion enhancing factor adsorbed on the surface of the matrix, wherein the three-dimensional porous matrix is obtained by freeze-drying composite hydrogel of GelMA and polyacrylic acid grafted with N-hydroxysuccinimide, and the adhesion enhancing factor is polydopamine. The composite tissue adhesive disclosed by the invention has a porous structure and can absorb liquid for wetting a wound surface, and polyacrylic acid is provided with carboxylic acid groups with negative charges, so the hydration expansion effect of the tissue adhesive can be accelerated, a tissue surface drying speed can be accelerated, and the composite tissue adhesive has a liquid absorption amount of 500% or above; and the composite tissue adhesive provided by the invention has two components which can be bonded with amino groups on wound tissues, and the adhesion strength of the composite tissue adhesive with wet wound tissues can reach 180 kPa or above.

Description

technical field [0001] The invention relates to the technical field of wound surface adhesion, and more particularly to a composite tissue adhesive and a preparation method and application thereof. Background technique [0002] In surgical operations, larger wounds usually require medical sutures or staples for anastomosis and closure. In order to prevent bleeding or infection of the wound, tissue sealing glue (such as Baiyun medical glue) or dressings will be used to seal the gap. Filling and sealing. For some small gaps between tissues, tissue sealing glue is directly used to seal them. However, clinically, the wound surface is often accompanied by continuous exudation of blood or tissue fluid, and there is leakage, and the wound surface is relatively moist. Although some surgical sites are easy to clean up the exudate, it is difficult to clean up special parts such as deep wounds. Therefore, a tissue glue product that can well treat wet wounds is urgently needed. At pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06A61L24/00A61L24/04A61L24/10A61L26/00
CPCA61L24/104A61L24/06A61L24/046A61L24/0036A61L24/0031A61L24/001A61L26/0038A61L26/0019A61L26/0014A61L26/0085A61L26/008C08L89/00C08L79/04C08L33/02C08L79/02C08L77/04
Inventor 林丽敏唐东海邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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