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Method for verifying effect of SAG in preventing environmental anomaly related bone dysplasia

A dysplastic, correlative technique applied in the field of medical experiments to address problems such as deficiency

Pending Publication Date: 2021-05-14
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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Problems solved by technology

Therefore, it is necessary to seek a new method to prevent the occurrence and development of craniofacial deformities, prevent bone developmental deformities, and reduce treatment costs and risks for individuals with irregular work and rest. Corticosteroid-induced abnormal cerebellar development in mouse neonates suggests that SAG has the clinical potential to prevent bone dysplasia, but there is currently a lack of scientific methods to verify the effect of SAG in preventing environmental abnormality-related bone dysplasia

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  • Method for verifying effect of SAG in preventing environmental anomaly related bone dysplasia
  • Method for verifying effect of SAG in preventing environmental anomaly related bone dysplasia
  • Method for verifying effect of SAG in preventing environmental anomaly related bone dysplasia

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Embodiment Construction

[0031] The specific implementation manners of the present invention will be described in further detail below in conjunction with the accompanying drawings.

[0032] The invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided so that this disclosure will be thorough and complete. In the drawings, the size and relative sizes of structures and regions may be exaggerated for clarity.

[0033] like Figure 1-6 As shown, the present invention provides a method for verifying that SAG prevents environmental abnormality-related bone dysplasia, comprising the following steps:

[0034] S1: Changing the light conditions in the environment to induce the establishment of a bone dysplasia model in mice with environmentally disordered rhythms;

[0035] S2: analyze the mandible of mouse described in S1, the bone mass of femur tissue, bone morphology, detect the proliferative ability ...

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Abstract

The invention provides a method for verifying the effect of SAG in preventing environmental anomaly related bone dysplasia. The method comprises the following steps of changing the illumination condition in the environment, and inducing the establishment of a bone dysplasia model of an environmental rhythm disorder mouse; analyzing the bone mass and bone morphology of mandible and femur tissues of the rhythm disorder mouse, the multiplication capacity and collagen secretion capacity of corresponding cartilage cells and Hedgehog pathway related gene expression; and finally analyzing the treatment effect of the mandible and femur tissues of the mouse subjected to SAG treatment. According to the method for verifying the effect of the SAG in preventing the environmental anomaly related bone dysplasia provided by the invention, the influence of an illumination factor and time difference in the natural environment on bone growth and development can be simulated by constructing the illumination factor induced mouse bone dysplasia model, and by comparing the development conditions of the mandible and femur tissues before and after injection of the SAG, the effect of the SAG in preventing mandibular deficiency, short and deformed femur and the like can be effectively verified.

Description

technical field [0001] The invention relates to the field of medical experiments, in particular to a method for verifying that SAG prevents bone dysplasia related to environmental abnormalities. Background technique [0002] Cranio-maxillofacial dysplasia is a disease of abnormal growth and development of the cranium and jaw. The incidence rate in my country is as high as 29.3%. and severe cardiovascular and cerebrovascular diseases [Nakamura, T., et al., Noonan syndrome is associated with enhanced ERK activity, the repression of which can prevent craniofacial malformations. Proc NatlAcad Sci U S A, 2009.106(36): p.15436-41.]. At present, the main treatment method for craniofacial deformity is orthodontic correction. A conventional complete correction cycle takes 3-4 years. Deformity, the treatment of single correction method is limited, and it is easy to relapse. Therefore, exploring the pathogenesis of craniofacial deformities and realizing the early prevention of craniof...

Claims

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Application Information

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IPC IPC(8): A01K67/02C12Q1/6883G01N33/68
CPCA01K67/02C12Q1/6883G01N33/6887G01N33/6893A01K2227/105A01K2267/03C12Q2600/158G01N2333/78G01N2800/10
Inventor 陈莉莉余少玲唐清明
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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