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Angelica sinensis qi-bearing traditional Chinese medicine preparation combined olanzapine composition and application thereof

A composition, technology of olanzapine, applied in the field of medicine, can solve problems such as unreported

Inactive Publication Date: 2021-05-11
SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This study explores the synergistic effect of Danggui Chengqi Mixture on olanzapine in the treatment of schizophrenia. There is no report on the combination of Danggui Chengqi traditional Chinese medicine and olanzapine composition and its application.

Method used

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  • Angelica sinensis qi-bearing traditional Chinese medicine preparation combined olanzapine composition and application thereof
  • Angelica sinensis qi-bearing traditional Chinese medicine preparation combined olanzapine composition and application thereof
  • Angelica sinensis qi-bearing traditional Chinese medicine preparation combined olanzapine composition and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of embodiment 1 Angelica Chengqi Decoction

[0038] Take crude drug raw materials: 300 grams of rhubarb, 150 grams of Glauber’s salt, 300 grams of Angelica, 120 grams of Chenpi, 80 grams of Louren, 40 grams of Loupi. Boil twice the amount of water, keep for 45 minutes after boiling, pass the concoction through a 120-mesh sieve, add 3 times the amount of water for the second time, boil, keep for 40 minutes after boiling, pass the concoction through a 120-mesh sieve, combine the two concoctions, and concentrate to 1000ml, let it stand, take the supernatant through a 120-mesh sieve, concentrate to 800ml, and store it separately. Take Glauber's salt and dissolve it in 150ml of boiling water, pass through a 120-mesh sieve, and store it separately. Soak rhubarb in 1000ml of boiling water for 40 minutes, let it stand, take 300ml of the supernatant, pass the concoction through a 120-mesh sieve, and store it separately. Combine the above liquid medicines, conce...

Embodiment 2

[0039] The preparation of embodiment 2 Angelica Chengqi Granules

[0040] Take crude drug raw materials: 300 grams of rhubarb, 150 grams of Glauber’s salt, 300 grams of Angelica, 120 grams of Chenpi, 80 grams of Louren, 40 grams of Loupi. Boil twice the amount of water, keep for 45 minutes after boiling, pass the concoction through a 120-mesh sieve, add 3 times the amount of water for the second time, boil, keep for 40 minutes after boiling, pass the concoction through a 120-mesh sieve, combine the two concoctions, and concentrate to 1000ml, let it stand, take the supernatant through a 120-mesh sieve, concentrate to 800ml, and store it separately. Take Glauber's salt and dissolve it in 150ml of boiling water, pass through a 120-mesh sieve, and store it separately. Soak rhubarb in 1000ml of boiling water for 40 minutes, let it stand, take 300ml of the supernatant, pass the concoction through a 120-mesh sieve, and store it separately. Combine the above liquid medicines, concen...

Embodiment 3

[0041] The preparation of embodiment 3 Angelica Chengqi tablet / capsule

[0042] Take crude drug raw materials: 300 grams of rhubarb, 150 grams of Glauber’s salt, 300 grams of Angelica, 120 grams of Chenpi, 80 grams of Louren, 40 grams of Loupi. Boil twice the amount of water, keep for 45 minutes after boiling, pass the concoction through a 120-mesh sieve, add 3 times the amount of water for the second time, boil, keep for 40 minutes after boiling, pass the concoction through a 120-mesh sieve, combine the two concoctions, and concentrate to 1000ml, let it stand, take the supernatant through a 120-mesh sieve, concentrate to 800ml, and store it separately. Take Glauber's salt and dissolve it in 150ml of boiling water, pass through a 120-mesh sieve, and store it separately. Soak rhubarb in 1000ml of boiling water for 40 minutes, let it stand, take 300ml of the supernatant, pass the concoction through a 120-mesh sieve, and store it separately. Combine the above medicinal liquids,...

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Abstract

The invention relates to the technical field of medicine, in particular to an angelica sinensis qi-bearing traditional Chinese medicine preparation combined olanzapine composition and application thereof. The traditional Chinese medicine preparation is prepared from the following raw material medicines in parts by weight of 300 parts of rheum officinale, 150 parts of mirabilite, 300 parts of angelica sinensis, 120 parts of pericarpium citri reticulatae, 80 parts of semen trichosanthis, 40 parts of trichosanthes kirilowii peel and 0.5 part of ethylparaben. The ratio of the traditional Chinese medicine preparation to the olanzapine is that the crude drug amount of the traditional Chinese medicine preparation is 990.5 g to the olanzapine is 16.00 mg. The invention further discloses application of the Chinese angelica qi-bearing traditional Chinese medicine preparation combined olanzapine composition in preparation of drugs for treating schizophrenia. The composition has the advantages that the Chinese angelica qi-bearing traditional Chinese medicine preparation and olanzapine synergistically act, so that the curative effect of olanzapine can be improved, the cognitive symptoms of patients can be improved, the adverse reaction of olanzapine can be relieved, and the composition is worthy of clinical popularization.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an angelica chengqi traditional Chinese medicine combined with olanzapine composition and application thereof. Background technique [0002] Schizophrenia is a severe mental illness with unknown etiology, high relapse rate and high disabling rate. The current treatment of schizophrenia is mainly based on antipsychotic drugs, regardless of the first-generation antipsychotic drugs or atypical antipsychotic drugs, the treatment effect on positive symptoms of schizophrenia patients is significant, but for negative symptoms, cognitive symptoms The curative effect is limited, and the adverse reactions of different antipsychotic drugs are different in the course of clinical application. Drug-induced adverse reactions and residual negative symptoms and cognitive impairment symptoms will lead to poor prognosis, poor treatment dependence, and difficulty in recovering social function. Ol...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P25/18A61K31/551A61K33/04
CPCA61K31/551A61K33/04A61K36/232A61K36/428A61K36/708A61K36/752A61P25/18A61K2300/00
Inventor 朱丽萍琚明亮龙彬陈剑华赵静孙杨孙萍张建明卢卫红
Owner SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
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