Chemical exchange saturation transfer quantitative method and device for magnetic resonance and medium

A chemical exchange and magnetic resonance technology, applied in the field of biomedical engineering, can solve the problems of inaccurate and stable CEST quantification, underestimated CEST effect, and increased scan time

Pending Publication Date: 2021-05-04
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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Problems solved by technology

However, the saturation time is limited by factors such as the hardware system and specific absorption rate, and long-term saturation and recovery will greatly increase the scan time, which is very difficult in practical applications
In the prior art, most CEST imaging studies are usually carried out under condi...

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  • Chemical exchange saturation transfer quantitative method and device for magnetic resonance and medium
  • Chemical exchange saturation transfer quantitative method and device for magnetic resonance and medium
  • Chemical exchange saturation transfer quantitative method and device for magnetic resonance and medium

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Embodiment 1

[0096] The chemical exchange process of water, semi-solid macromolecules and amide protons (amide) is simulated using the classic three-cell Bloch McConnell equation. Assuming a 11.7Tesla magnetic field environment, the longitudinal relaxation rate of water is 0.5Hz and the transverse relaxation rate is 30Hz; the longitudinal relaxation rate of amide protons is 1Hz and the transverse relaxation rate is 66.7Hz; Relaxation rate 105Hz. The proportions of amide protons (resonance frequency at 3.5 ppm relative to water) and semisolid macromolecules (resonance frequency at 0 ppm relative to water) relative to water were 0.1% and 13.9%, corresponding to exchange rates of 30 Hz and 23 Hz. Set the saturation energy amplitude (B1) to 1μT, the saturation time (Ts) / recovery time (Td) to 2s / 2s and 4s / 4s respectively, and simulate the CEST signal in the range of -4.5 to 4.5ppm with 0.1ppm as the step size. The CEST signal and the CEST effect are calculated by the chemical exchange saturati...

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Abstract

The invention discloses a chemical exchange saturation transfer quantitative method and device for magnetic resonance and a medium, and belongs to the field of biomedical engineering. The chemical exchange saturation transfer quantitative method comprises the following steps of: acquiring a longitudinal relaxation rate of water; presetting a deformation formula for calculating the spin lock relaxation rate of water on the basis of an unsteady-state experiment condition, wherein at least one deformation parameter of the deformation formula is a ratio of a saturation signal to an unsaturation reference signal under the unsteady-state experiment condition; acquiring a plurality of parameters under an unsteady state experiment condition, calculating a deformation formula according to the parameters, and acquiring the spin lock relaxation rate of water; based on the longitudinal relaxation rate of water and the spin lock relaxation rate of water, acquiring a magnetic resonance chemical exchange saturation transfer signal under a steady-state experiment condition; and acquiring the magnetic resonance chemical exchange saturation transfer effect under the steady-state experiment condition based on the signal. According to the chemical exchange saturation transfer quantitative method and the device, the steady-state CEST signal can be calculated and obtained based on the unsteady-state CEST signal, so that the influence of the imaging parameter on a CEST quantitative result is removed, and the accuracy of CEST quantification is improved.

Description

technical field [0001] The application relates to the field of biomedical engineering, in particular to a chemical exchange saturation transfer quantitative method, device and medium for magnetic resonance. Background technique [0002] Magnetic resonance chemical exchange saturation transfer (CEST) imaging is an important imaging method for non-invasively obtaining molecular information of biological tissues using endogenous or exogenous CEST contrast agents. Sufficient saturation of the CEST contrast agent and sufficient recovery of the water molecule signal after saturation are necessary conditions for obtaining a steady-state CEST signal, which determine the accuracy of the quantification of the CEST effect. [0003] The quantification of the CEST effect is very complex, affected by many factors, and closely related to important imaging parameters such as saturation time (Ts) and recovery time (Td), that is, the quantitative results of CEST are highly dependent on imagin...

Claims

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Application Information

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IPC IPC(8): G01R33/561A61B5/055
CPCG01R33/561A61B5/055
Inventor 吴垠孙哲郑海荣刘新
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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