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Detection method of gas-phase fingerprint of 'Zhengqi' tablets and application of detection method

A fingerprint and detection method technology, which is applied in the field of traditional Chinese medicine component detection, can solve the lack of qualitative research on the volatile components of Zhengqi Tablets, and achieve the effects of ensuring safety and effectiveness, simple operation, good precision and repeatability

Pending Publication Date: 2021-05-04
HEHUANG PHARMA SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The composition of Zhengqi tablets contains a large number of volatile components. At present, there is a lack of systematic qualitative research on the volatile components of Zhengqi tablets. Therefore, it is necessary to establish a gas-phase fingerprint of Zhengqi tablets to complete the qualitative analysis of the components in Zhengqi tablets. Control the quality of Zhengqi tablets

Method used

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  • Detection method of gas-phase fingerprint of 'Zhengqi' tablets and application of detection method
  • Detection method of gas-phase fingerprint of 'Zhengqi' tablets and application of detection method
  • Detection method of gas-phase fingerprint of 'Zhengqi' tablets and application of detection method

Examples

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Effect test

preparation example Construction

[0092]Preparation of the test solution: Precisely referred to the positive tube powder 10g, placed in 50 ml of EP tube, precisely addition of absolute ethanol 15-25ml, weighing weight, and the deoxy is closed with ultrasonic instrument to extract 20-40 min, again Weighing, with anhydrous ethanol replenish the weight loss, centrifuge at 2000-4000 r / min, taking the supernatant, filtered with a film having a pore diameter of 0.22 μm, that is, the test solution is obtained.

[0093]Preparation of the substance solution: It is precisely referred to, respectively, dehydroxide, tractone, tractone, placed in a capacity bottle for step-by-step dilution. Adding anhydrous ethanol is dissolved and uniform in a capacity bottle, and the concentration of each component is 0.5 mg / ml in the reserved reserve solution, and the storage temperature of the reserve solution is 0-5. ° C. The reserved reserved solution was added to anhydrous ethanol, and the concentration of each component in the substance...

Embodiment 1

[0112]1, sample before sample

[0113]Preparation of the test solution: Precisely referred to the positive tube powder 10g, placed in 50 ml of EP tube, precision addition of water absorbed ethanol, weighing weight, and extracts 30 min after the sonicator is closed, and again, use The weight loss of water was reduced, centrifuged at 3000 R / min for 20 min, and the supernatant was taken, filtered with a film having a pore diameter of 0.22 μm, and the test solution was obtained.

[0114]Preparation of the solution solution: It is precisely known as a woodhyductone, dehydroquidine, and an attrial plexus control. That is, 5 mg of the control product is first placed in a 10ml capacity bottle, and anhydrous ethanol is dissolved and shaken in a capacity bottle, and the concentration of each component is 0.5mg / ml in the reserve solution of the reserve solution. The storage temperature of the reserve solution is 4 ° C. The reserved reserve solution was added to anhydrous ethanol diluted and conf...

Embodiment 2

[0120]The detection method of the gas phase fingerprint of the positive tap established in the above examples was detected, and the gas phase fingerprint of the test solution was obtained, and the gas phase fingerprint of the test solution, 10 batches of positive air The batch number is shown in Table 2. The gas phase fingerprus spectrum data of the obtained test product is imported into the "Chinese Medicine Color Fingerprint Similarity Evaluation System" 2009 software released by the National Pharmacopoeia Commission, and the standard gas phase fingerprint of the normal gas obtained under the same fingerprint spectrum detection conditions is similar. In comparison, the similarity of the gas phase fingerprint of the positive gas and the standard gas phase fingerprint of the positive sheet is ≥0.95 as the standard, and the reference peak (S peak, the retention time is 1.000), and the standard fingerprint of the positive sheet is determined by the reference peak (S peak, the retentio...

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Abstract

The invention provides a detection method of a gas-phase fingerprint of 'Zhengqi' tablets. The detection method comprises the following steps of: 1) preparing a test solution; 2) preparing a reference substance solution; and 3) carrying out determination. The invention further provides application of a gas-phase fingerprint of the 'Zhengqi' tablets in quality detection of components in the 'Zhengqi' tablets and a quality detection method of the gas-phase fingerprint of the 'Zhengqi' tablets. The invention further provides a gas phase fingerprint screening method of multiple medicinal materials in the 'Zhengqi' tablets. According to the detection method of the gas phase fingerprint of the Zhengqi tablet and the application of the detection method, the gas phase fingerprint of the Zhengqi tablet is established, the chromatographic peak of each single medicinal material in the Zhengqi tablet is subjected to affiliation confirmation, effective monitoring can be carried out from a raw material source, the quality of the raw medicinal materials is strictly controlled, and the amount of effective components in the Zhengqi tablet is relatively stable, so that the safety and effectiveness of clinical medication are ensured.

Description

Technical field[0001]The present invention belongs to the technical field of Chinese medicine component detection, and the method of detecting a gas phase fingerprint spectrum of a positive sheet and its application thereof, specifically, a method of detecting a gas phase fingerprint spectrum of a positive amount and its application in quality detection.Background technique[0002]COVID-19 The disease has a typical diver's disease, which belongs to the "epidemic disease" of Chinese medicine. It shows that the wet stop, the lung loss is preliminary, and the patient is hot, the patient has more tongue whitening, stool, the disease It is longer than the general respiratory infection, which is very easy to consolidate, and therefore it should be supplemented by wet. "New Coronary Virus Pneumonia Media" (Trial) Seventh Edition was released on March 3, 2020, which will include Huoxiang Zhengqi, including Huoxiang Zhengqi, as a medical observation period, with gastrointestinal discomfort Pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/8809
Inventor 沈丹萍张正光詹常森姜鹏温方方
Owner HEHUANG PHARMA SHANGHAI
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