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Preparation method of stretchable hydrogel, stretchable hydrogel and application

A technology of hydrogel and bacterial cellulose, which is applied in the field of biomedical materials, can solve the problems of unsatisfactory coverage and fixation, and lack of antibacterial properties, and achieve good biocompatibility and biodegradability, good stretching and adhesion The effect of supplementary performance and great clinical value

Active Publication Date: 2021-03-30
THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002]The most common existing clinical dressing is cotton gauze dressing, which is not ideal for covering and fixing joints and skin folds, and does not have antibacterial properties. Frequent replacement, etc., so it is of certain value to develop a stretchable, adhesive and biocompatible hydrogel

Method used

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  • Preparation method of stretchable hydrogel, stretchable hydrogel and application
  • Preparation method of stretchable hydrogel, stretchable hydrogel and application
  • Preparation method of stretchable hydrogel, stretchable hydrogel and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A kind of stretchable hydrogel, its preparation process is as follows:

[0029] S1. Take 4ml of 0.55-0.65%wt bacterial cellulose dispersion, add it to a centrifuge tube, and then dilute to 10ml with deionized water;

[0030] S2. Add 0.2 g of ammonium persulfate and 0.015 g of dopamine to the diluted bacterial cellulose dispersion obtained in step S1, stir at room temperature for about 30 min, and the mixture turns from white to brown;

[0031] S3. Add 2.5 g of acrylamide, 0.015 g of N,N-methylenebisacrylamide, and 20 μl of tetramethylethylenediamine to the system in step S2 under ice bath conditions, and stir for 10 min. After returning to room temperature, the mixture is The brown color becomes brownish red, and then the mixture is poured into a petri dish, and placed in a 60°C incubator for 2-3 hours, or placed at room temperature for 48 hours, to obtain a stretchable hydrogel.

Embodiment 2

[0033] A kind of stretchable hydrogel, its preparation process is as follows:

[0034] S1. Take 4ml of 0.55-0.65%wt bacterial cellulose dispersion, add it to a centrifuge tube, and then dilute to 10ml with deionized water;

[0035] S2. Add 0.2 g of ammonium persulfate and 0.01 g of dopamine to the diluted bacterial cellulose dispersion obtained in step S1, stir at room temperature for about 30 min, and the mixture turns from white to brown;

[0036] S3. Add 2 g of acrylamide, 0.015 g of N,N-methylenebisacrylamide, and 10 μl of tetramethylethylenediamine to the system in step S2 under ice bath conditions, and stir for 10 min. After returning to room temperature, the mixture turns from brown to It turns brownish red, and then the mixture is poured into a petri dish, and placed in a 60°C incubator for 2-3 hours, or placed at room temperature for 48 hours, to obtain a stretchable hydrogel.

Embodiment 3

[0038] A kind of stretchable hydrogel, its preparation process is as follows:

[0039] S1. Take 4ml of 0.55-0.65%wt bacterial cellulose dispersion, add it to a centrifuge tube, and then dilute to 10ml with deionized water;

[0040] S2. Add 0.2 g of ammonium persulfate and 0.02 g of dopamine to the diluted bacterial cellulose dispersion obtained in step S1, stir at room temperature for about 30 min, and the mixture turns from white to brown;

[0041]S3. Continue to add 3g of acrylamide, 0.015g of N,N-methylenebisacrylamide, and 30μl of tetramethylethylenediamine to the system in step S2 under ice bath conditions, and stir for 10min. After returning to room temperature, the mixture turns from brown to It turns brownish red, and then the mixture is poured into a petri dish, and placed in a 60°C incubator for 2-3 hours, or placed at room temperature for 48 hours, to obtain a stretchable hydrogel.

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Abstract

The invention discloses a preparation method of stretchable hydrogel, the stretchable hydrogel and application. The preparation method of the stretchable hydrogel comprises the following steps of 1, preparing bacterial cellulose dispersion liquid with the mass fraction of 0.1-0.4 wt%; S2, adding ammonium persulfate and dopamine into the diluted bacterial cellulose dispersion liquid obtained in thestep S1, and conducting stirring for 15-60 minutes at room temperature until the mixed liquid becomes brown from white; and S3, continuously adding acrylamide, N,N-methylene bisacrylamide and tetramethylethylenediamine into the system in the step S2 under an ice bath condition, conducting stirring for 5-30 minutes, after the room temperature is recovered, pouring the mixed solution changing frombrown to brownish red into a vessel, putting the vessel into an incubator at 55-65 DEG C for 2-3 hours, or conducting standing at the room temperature for 40-60 hours to obtain the stretchable hydrogel. The stretchable hydrogel has good stretchability and adhesion, and can be used for preparing medical dressings.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular, the invention relates to a preparation method of a stretchable hydrogel, a stretchable hydrogel and applications thereof. Background technique [0002] The most common existing clinical dressing is cotton gauze dressing. Its coverage and fixation on joints and skin folds is not ideal, and it does not have antibacterial properties and must be replaced frequently. Therefore, a stretchable, adhesive dressing is developed. Hydrogels with good performance and good biocompatibility are of some value. [0003] The polymers that form hydrogels are water-soluble or hydrophilic, and the coagulation principle includes chemical cross-linking or physical cross-linking. Macromolecules can be divided into two categories: natural and synthetic according to their sources: natural hydrophilic macromolecules include polysaccharides (starch, cellulose, alginic acid, hyaluronic acid, chit...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L33/26C08L79/04C08L1/02C08F220/56C08F222/38A61L26/00
CPCC08J3/075C08F220/56A61L26/008A61L26/0061A61L26/009A61L26/0052C08J2333/26C08J2479/04C08J2401/02C08L33/26C08L79/04C08L1/02C08F222/385
Inventor 杨梓锋王辉李创坤过文泰曾展涛黄榕康王怀明胡民辉秦秀森张迪陈春吴小剑兰平汪建平
Owner THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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