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Use of arteether maleate amine for preparation of ophthalmic preparations

A kind of application, the technology of Artemisia vulgaris is applied in the application field of arteetheramine maleate for preparing ophthalmic preparations, and achieves the effects of increasing mucin secretion, increasing tear secretion and good clinical application prospect.

Pending Publication Date: 2021-03-30
JIANGSU ZUOYOU MEDICINE CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no application or report of arteetheramine maleate in the treatment of ocular inflammatory injury caused by insufficient tear secretion

Method used

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  • Use of arteether maleate amine for preparation of ophthalmic preparations
  • Use of arteether maleate amine for preparation of ophthalmic preparations
  • Use of arteether maleate amine for preparation of ophthalmic preparations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1. Preparation of Malenlanaceaide Ethemide Eye Preparation

[0026] The specific preparation method of maleate (SM934) (SM934) can refer to the applicant (ZL93112454.9) and published papers J. Med.Chem, 2000, 43: 1635-1640 ..

[0027] SM934:

[0028] Salt with maleic acid. White crystals. Melting point: 139-141 ° C

[0029] Element analysis (C 21 Hide 33 NO 9 ):

[0030] Calculated value: C 56.87 h 7.50 n 3.16

[0031] Measured value: C 56.84 h 7.59 n 3.10

[0032] The ophthalmic preparation according to the present embodiment, is a drop of eye, and is 10.5 g or 0.1 g of a maleate, 0.8 g of sodium chloride, 0.02 g of potassium chloride, sodium hydrogen sodium chloride. 0.2924 g, potassium dihydrogen phosphate 0.02 g, pH 7.37.

[0033] Preparation method: 8g of sodium chloride, 0.2 g of potassium chloride, 2.924 g of hydrogen phosphate, 0.2 g of phosphate, dissolved in 1L distilled water, room temperature, mix well, produce pH 7.39 solution For solution A.

[0034] T...

Embodiment 2

[0035] Example 2. Thermal artilletted ethyl amine drops prepared by EtOAc EtOAc EtOAc

[0036] 1. Main experimental materials and sources

[0037] (1) Animals: SPF-grade SD rats, female, weight 120-150g, provided by Shanghai Jiejie Experimental Animal Co., Ltd., Qigsy Certificate No .: 20180004006541.

[0038] (2) Main experimental drugs and reagents

[0039]Malenana, a pharmaceutical: White powder, a drop of eye drops (0.5 W / V% male), pH 5.91; 0.1W / V% maleic acid according to Example 1 Hertian anacide drops, pH 6.89).

[0040] Reagents: Eastern Alkalihydrobromide, purchased from National Medicine Group Chemical Reagents Co., Ltd., CAS: 6533-68-2, Production Bottom: # f1713061. It was made of 1.5 W / V%, 1.75w / V% concentration in sterile water. Glass-sodium acid drops, by the Participate Pharmaceutical Co., Ltd. Can Ltd. Approval number: National Drug Standard J20130150. Tears detection of phenol red cotton line, produced by Tianjin Jingming New Technology Development Co., L...

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Abstract

The present invention relates to the use of arteether maleate amine (SM934) for the preparation of ophthalmic preparations, and more particularly, to the use of arteether maleate amine for the preparation of ophthalmic preparations for the prevention or treatment of ocular inflammatory injuries caused by insufficient tear secretion.

Description

Technical field [0001] The present invention relates to the use of a new use of a molantide a ether amine, and the present invention is specifically a use of ethyl esterine in the preparation of an ophthalmic preparation for the treatment of tears. Background technique [0002] Dry eye, also known as dry cornea conjunctivitis, refers to a class of diseases of a type of disease due to the quality or amount of tears or an ocular discomfort caused by tear liquid kinetics. The clinical manifestation is a dry feeling, burning, foreign body sensation, itching, crying, eye red, blurred vision, vision and visual fatigue. Severe dry eyes can also cause corneal inflammation, corneal blood vessels, corneal ulcers, etc. Dry eye is mainly divided into lack of tears and evaporative overvoltage, meibus gland function disorders, dry syndrome, vitamin A deficiency, allergies, pregnancy, drug treatment can cause dry eye disease. With the development of social and economic development and increasin...

Claims

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Application Information

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IPC IPC(8): A61K31/357A61P27/02
CPCA61K31/357A61P27/02
Inventor 左建平何世君唐炜杨晓倩杨芳明李平
Owner JIANGSU ZUOYOU MEDICINE CO LTD
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