A kind of notoginseng saponin-hydrogel pulp capping agent material and preparation method thereof

A technology of notoginseng saponin and hydrogel, which is applied in the field of pulp sealing materials, can solve the problems of lack of intrinsic ability and achieve strong anti-inflammatory ability and strong effect of inducing restorative dentin formation

Active Publication Date: 2022-03-08
HANGZHOU HUIBO SCI & TECH CO LTD
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  • Claims
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Problems solved by technology

Nonetheless, Gel-MA still lacks the intrinsic ability to alleviate inflammation and induce dentinogenesis

Method used

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  • A kind of notoginseng saponin-hydrogel pulp capping agent material and preparation method thereof
  • A kind of notoginseng saponin-hydrogel pulp capping agent material and preparation method thereof
  • A kind of notoginseng saponin-hydrogel pulp capping agent material and preparation method thereof

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Embodiment Construction

[0032] The present invention will be further described below in conjunction with the examples. The description of the following examples is provided only to aid the understanding of the present invention. It should be pointed out that for those skilled in the art, some modifications can be made to the present invention without departing from the principles of the present invention, and these improvements and modifications also fall within the protection scope of the claims of the present invention.

[0033] NGR1 can significantly promote the expression of osteocalcin (OCN), a marker of dentinogenic differentiation, and the mineralization of extracellular matrix. Preliminary studies have shown that NGR1 can also effectively induce extracellular matrix mineralization (a marker of terminal dentine differentiation) in odontoblast-like cells and human primary dental pulp stem cells. NGR1 has broad application prospects in pulp capping therapy.

[0034] 1. Characterization of the ...

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Abstract

The present invention relates to a kind of notoginsenoside-hydrogel pulp capping agent material and its preparation method, comprising: step 1, synthesizing gelatin methacrylate (Gel-MA); step 2, preparing load line type ginsenoside R1 (NGR1 ) of gelatin methacrylate and linear ginsenoside R1 composite hydrogel (Gel‑MA / NGR1 composite hydrogel). The beneficial effects of the present invention are: the present invention proposes a photocrosslinkable Gel-MA / NGR1 composite hydrogel as a substitute material for pulp capping agents; the composite hydrogel has strong anti-inflammatory ability and inductive repair property The ability of dentin to form. The physicochemical properties of the photocrosslinkable Gel‑MA / NGR1 composite hydrogel and its efficacy in inducing dentin formation in vitro and reparative dentin formation in vivo were also investigated.

Description

technical field [0001] The invention belongs to the technical field of pulp sealing materials, and in particular relates to a notoginsenoside-hydrogel pulp capping agent material and a preparation method thereof. Background technique [0002] Dental pulp is the highly vascularized and innervated connective tissue that provides nourishment, protection and defense to the tooth. The pulp is also highly sensitive and susceptible to irritation by pathogens such as bacteria, and to damage by bacterial products. Under the stimulation of deep caries and trauma, the dental pulp may develop irreversible pulpitis, leading to pulp necrosis, apical periodontitis, and potential systemic complications such as osteomyelitis and bacteremia. [0003] In order to maintain the vitality of the pulp tissue, pulp sealing materials are used clinically to cover the exposed or infected pulp. Pulp sealing materials should meet a series of basic requirements, such as: short setting time, adhesion to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/884A61K6/69A61K6/62A61K6/20A61K6/15
CPCA61K6/884A61K6/69A61K6/62A61K6/20A61K6/15C08L89/06
Inventor 王磊吴刚柳毅潘乙怀傅晖李伶俐林振卢云宇吴丽勇
Owner HANGZHOU HUIBO SCI & TECH CO LTD
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