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High-strength medical gel material and preparation method thereof

A gel material and high-strength technology, which is applied in the field of high-strength medical gel material and its preparation, can solve the problems of poor PHEMA strength and water absorption capacity, and achieve the effect of improved toughness and high strength

Pending Publication Date: 2021-03-26
HEFEI GENIUS NEW MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, it is necessary for the present invention to provide a high-strength medical gel material and its preparation method. By modifying PHEMA, the problems of poor strength and poor water absorption capacity of PHEMA in the prior art are solved.

Method used

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  • High-strength medical gel material and preparation method thereof

Examples

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Effect test

Embodiment 1

[0027] According to parts by weight, dissolve 1 part of hyaluronic acid in deionized water to obtain a colloidal solution; add 98.7 parts of poly-2-hydroxyethyl methacrylate to the above colloidal solution, and stir at 85°C for 6 hours to obtain a polymer mucus Remove bubbles from the polymer mucus under ultrasonic conditions, pour it into a Teflon reactor for freezing (-20°C)-thawing (35°C) cycle reaction for 1 hour (freezing and thawing each for 0.5h); Put the gel in an oven and heat it to 125°C for 1.5 hours; take 0.3 parts of CaCl 2 Prepare CaCl with a concentration of 0.08mol / L 2 solution, the dried gel was immersed in CaCl 2 After soaking in the solution for 40 hours, wash with deionized water to obtain PHEMA / HA-Ca 2+ Material; PHEMA / HA-Ca 2+ After the material is subjected to freezing (-20°C)-thawing (35°C) cycle reaction in a Teflon reactor, it is placed in an oven and heated to 125°C and then kept for 2 hours to obtain a high-strength medical gel material.

Embodiment 2

[0029] According to parts by weight, dissolve 1.2 parts of hyaluronic acid in deionized water to obtain a colloid solution; add 98.4 parts of poly-2-hydroxyethyl methacrylate to the above colloid solution, and stir at 80°C for 5 hours to obtain a polymer mucus Remove bubbles from the polymer mucus under ultrasonic conditions, pour it into a Teflon reactor for freezing (-25°C)-thawing (32°C) cycle reaction for 1 hour (freezing and thawing each for 0.5h); Put the gel in an oven and heat it to 130°C for 2 hours; take 0.4 parts of CaCl 2 Prepare CaCl with a concentration of 0.1mol / L 2 solution, the dried gel was immersed in CaCl 2 After soaking in the solution for 48 hours, wash with deionized water to obtain PHEMA / HA-Ca 2+ Material; PHEMA / HA-Ca 2+ After the material is subjected to freezing (-25°C)-thawing (32°C) cycle reaction in a Teflon reactor, it is placed in an oven and heated to 130°C and then kept for 2 hours to obtain a high-strength medical gel material.

Embodiment 3

[0031] According to parts by weight, dissolve 0.8 parts of hyaluronic acid in deionized water to obtain a colloidal solution; add 98.9 parts of poly-2-hydroxyethyl methacrylate to the above colloidal solution, and stir at 90°C for 7 hours to obtain a polymer mucus Remove bubbles from the polymer mucus under ultrasonic conditions, pour it into a Teflon reactor for freezing (-18°C)-thawing (38°C) cycle reaction for 1.5 hours (freezing and thawing each 0.75h); Put the gel in an oven and heat it to 135°C for 2.5 hours; take 0.3 parts of CaCl 2 Prepare CaCl with a concentration of 0.15mol / L 2 solution, the dried gel was immersed in CaCl 2 After soaking in the solution for 60 hours, wash with deionized water to obtain PHEMA / HA-Ca 2+ Material; PHEMA / HA-Ca 2+ After the material is frozen (-18°C)-thawing (38°C) cycle reaction in a Teflon reactor, it is placed in an oven and heated to 135°C and then kept for 2.5 hours to obtain a high-strength medical gel material.

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Abstract

The invention discloses a high-strength medical gel material and a preparation method thereof. The high-strength medical gel material is prepared from the following components in parts by weight: 98.0-99.3 parts of 2-hydroxyethyl methacrylate, 0.5-1.5 parts of hyaluronic acid and 0.2-0.5 parts of CaCl2. Through modification of PHEMA, the problem that in the prior art, PHEMA is poor in strength andpoor in water absorption capacity is solved. Hyaluronic acid (HA) and CaCl2 are used for modifying the PHEMA gel material, and the obtained gel material has higher strength and higher water content.

Description

technical field [0001] The invention belongs to the field of gel material modification, and in particular relates to a high-strength medical gel material and a preparation method thereof. Background technique [0002] 2-Hydroxyethyl methacrylate (abbreviated as HEMA in English) is a functional monomer synthesized by researchers at DU PONT in 1936. As a traditional bio-based material, HEMA monomer and its polymers have good biocompatibility, and are widely used in tooth filling, drug sustained release, burn coating, organ transplantation, contact lens manufacturing, cell culture and Immobilization of biomolecules and enzymes, etc. [0003] Poly(2-hydroxyethyl methacrylate) (PHEMA for short) gel material is a copolymer hydrogel mainly composed of 2-hydroxyethyl methacrylate monomer, but due to its poor mechanical strength , insufficient permeability, and weak water absorption capacity have limited its application. At present, the commonly used method of strengthening gel ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J7/14C08J9/28C08J9/40C08L33/14C08L5/08
CPCC08J3/075C08J7/14C08J9/40C08J9/28C08J2333/14C08J2405/08
Inventor 杨桂生计娉婷朱敏廖雄兵姚晨光
Owner HEFEI GENIUS NEW MATERIALS
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