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Application of garlic-derived substances in treatment and/or prevention of psoriasis

A technology of garlic, uses, applied in the field of medicine, can solve the problems of serious infection, safety restrictions, increased risk of adverse cardiovascular events, etc.

Pending Publication Date: 2021-03-23
新疆胡蒜研究院(有限公司)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In short, the various chemical drugs currently used in the treatment of psoriasis have certain adverse reactions, and cannot achieve an effective cure.
Biologics have improved outcomes in patients with psoriasis vulgaris, but safety concerns limit their use, including risk of serious infections (eg, tuberculosis) and increased risk of malignancy or major adverse cardiovascular events
In addition, expensive biologics are a heavy burden on patients

Method used

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  • Application of garlic-derived substances in treatment and/or prevention of psoriasis
  • Application of garlic-derived substances in treatment and/or prevention of psoriasis
  • Application of garlic-derived substances in treatment and/or prevention of psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0144] The preparation of embodiment 1 ointment and hydrogel

[0145] Garlic is divided into cloves, peeled, cleaned, sterilized, sliced, dried, crushed, and sieved to obtain garlic powder.

[0146] Garlic is divided into cloves, peeled, cleaned, sterilized, enzyme-inactivated, sliced, dried, crushed, and sieved to obtain enzyme-inactivated garlic powder.

[0147] Garlic is divided into cloves, peeled, washed, sterilized, inactivated, homogenized, filtered, concentrated, recrystallized, dried, crushed, and sieved to obtain alliin.

[0148] Garlic is divided into cloves, peeled, washed, sterilized, homogenized, filtered to remove slag, dried, crushed, and sieved to obtain allinase.

[0149] Following Table 2 formula prepares ointment according to the following method:

[0150] Heat and melt white vaseline at 60°C, add glyceryl stearate, stir, add liquid paraffin when the temperature drops to 50°C, and stir to form a uniform matrix. After the matrix temperature drops to 45°C, ...

Embodiment 2

[0157] Embodiment 2 animal experiments

[0158] Male Balb / c mice, weighing 18-22 g, were randomly divided into groups of 6 mice.

[0159] Shave off the hair on the back of the mouse, and expose the skin of the mouse to an area of ​​about 3cm×2cm in size. Except for the blank group, apply imiquimod on the exposed skin on the back of the mice in other groups every day at noon, 62.5mg / time, 1 time / time days, 8 consecutive days.

[0160] Since the 5th day of imiquimod application, in addition to the blank group and the model group, experimental 1, 4-6 groups were given the ointment prepared according to formula 1, 4-6 in Example 1, experimental 2 and 3 groups Give the hydrogel prepared in Example 1 while giving the ointment prepared according to formula 2 and 3 in Example 1 respectively, and mix the ointment and hydrogel in a ratio of 1:1 before administration, Each group took 1 time / day in the morning and evening, 140mg ointment / time / piece, for 4 consecutive days.

[0161] Durin...

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Abstract

The invention relates to alliin derived from garlic, allicin as an enzyme catalytic product of alliin, diallyl monosulfide, diallyl disulfide, diallyl trisulfide, dehydrated garlic, dehydrated garlicwith inactivated alliinase, and the like, which are used for preventing and / or treating psoriasis.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of garlic-derived substances in treating and / or preventing psoriasis. Background technique [0002] Psoriasis (Psoriasis), commonly known as psoriasis, is an autoimmune skin disease mediated by chronic inflammation and immunity. The histopathological manifestations are mainly hyperkeratosis of keratinocytes in the basal layer of the epidermis with parakeratosis, proliferation and expansion of capillaries in the dermis, and infiltration of inflammatory cells. The most common clinical manifestations are dryness, erythema, plaques, and scales. Most of the patients of this disease are young and middle-aged people, which has a great negative impact on the physical health and mental status of the patients. At present, about 2% of young and middle-aged people in the world are suffering from the disease, which seriously affects normal life and study. According to incomplete ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/255A61K31/198A61K36/8962A61K38/51A61K9/06A61K47/44A61K47/06A61K47/10A61K47/32A61P17/06
CPCA61K9/06A61K31/198A61K31/255A61K36/8962A61K38/51A61K47/06A61K47/10A61K47/32A61K47/44A61P17/06C12Y404/01004A61K2300/00
Inventor 李新霞王岩宋百灵史荣梅张春子肖文浚张海峰马雪红
Owner 新疆胡蒜研究院(有限公司)
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