Application of pectolinarin in preparation of medicine for treating glucolipid metabolism diseases and medicinal composition
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A technology for glucose and lipid metabolism and damarin, which is applied in the field of medicine, can solve the problems of slow onset of traditional Chinese medicine ingredients, cannot achieve radical cure, and has little effect, and achieves good application and development prospects, weight reduction, and blood lipid regulation.
Pending Publication Date: 2021-03-19
GUANGDONG PHARMA UNIV
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Nogo-B inhibitors, also known as reticulin or Nogo-B protein, can be located in the endoplasmic reticulum and related to endoplasmic reticulum tube membrane proliferation and membrane bending. play a radical role
The patent publication No. CN10539565.4A discloses a traditional Chinese medicine composition for preventing glucose metabolism disorder and its preparation method, and further discloses that the traditional Chinese medicine composition includes bergamot extract, Panax notoginseng saponin extract, Ligustrum lucidum total Organic acid extract, this traditional Chinese medicine formula has clear active ingredients and a stable preparation process, which can improve the efficacy of preventing and treating diseases of glucose metabolism disorders to a certain extent, but its effect is small, and the onset of Chinese medicine ingredients is slow
[0005] In summary, technical problems such as incomplete treatment, slow onset of effect, and inconspicuous effect generally exist in the prior art.
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Embodiment 1
[0023] Embodiment 1, the preparation of sardin tablet
[0024] Weigh 2.0kg of sardin, 1.0kg of starch, and 1.0kg of microcrystalline cellulose, mix them evenly, dry them at 80°C for 0.5h, put them into tablet-making equipment, and press them into tablets, making a total of 10,000 tablets, each 0.4g , Each tablet contains 200mg of sarcin.
Embodiment 2
[0025] Embodiment 2, the preparation of sardin capsules
[0026] Weigh 2.0kg sardin and 1.0kg starch, mix well, add 75% alcohol to granulate, dry, pass through a 20-mesh sieve but cannot pass through a 40-mesh sieve to obtain granules; use agar as raw material, mix with glycerin, dodecane Sodium sulfonate, polyacrylamide and natural pigments are mixed, and an appropriate amount of pure water is added to prepare a capsule solution, and the capsule solution is solidified through a capsule mold, demolded, cut, fitted, and sterilized to obtain a capsule coat; the above particles are packed into a capsule In the coat, that is. A total of 10,000 capsules were made, each capsule contained 0.3g of granules, and each capsule contained 200mg of sardin.
Embodiment 3
[0027] Embodiment 3, the preparation of sardin oral liquid
[0028] Weigh 3.0kg of sardine, wrap it in a filter bag, place it in an extraction tank, add 10 times the amount of water, extract 3 times at 90-120°C, the first time is 2 hours, and the remaining 2 times are 1 hour each time, combine the extracts, and filter , concentrated to a relative density of 1.05, cooled to 50°C, then added an aqueous solution of chitosan with a mass percentage of 1%, stirred for 0.5h, stood for 8h, added 10kg of crystalline maltitol after filtration, stirred to dissolve, and added pure water to set container, control the pH value to 6, fill, sterilize at 115°C for 0.5h, and cool to get ready.
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Abstract
The invention belongs to the technical field of medicines, and particularly relates to application of pectolinarin in preparation of a medicine for treating glycolipid metabolism diseases and a medicinal composition. According to the application of the pectolinarin in preparation of the medicine for treating the glycolipid metabolism diseases, experiments prove that the pectolinarin has the effects of reducing blood sugar of mice suffering from glycolipid metabolism disorder, regulating blood fat, reducing weight and reducing abdominal girth, can also promote L cells of intestinal tracts of the mice to secrete hypoglycemic hormone GLP-1 to achieve the effect of enhancing the insulin sensitivity, and can effectively treat the glycolipid metabolism diseases. The invention also provides the medicinal composition containing the pectolinarin. The medicinal composition comprises the pectolinarin and atractylenolide I. Compared with the pectolinarin, the medicinal composition has the advantages that the blood sugar is reduced, the blood fat is regulated, the effect of promoting the intestinal L cells to secrete the hypoglycemic hormone GLP-1 is more remarkable, and the medicinal composition has a good application prospect in the aspect of treating the glycolipid metabolism diseases.
Description
technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of sardin in the preparation of medicines for treating glucose and lipid metabolism diseases and its composition. Background technique [0002] Glucolipid metabolism disease refers to a disease characterized by disorders of glucose and lipid metabolism and is involved in multiple factors such as genetics, environment, and spirit. It is characterized by neuroendocrine disorders, insulin resistance, oxidative stress, inflammation, and intestinal flora disorders As the core pathology, hyperglycemia, dyslipidemia, fatty liver, overweight, hypertension, atherosclerosis and other single or combined occurrences are the main clinical manifestations, which require comprehensive prevention and control as a whole. Innovatively recognize and treat hyperlipidemia, diabetes, fatty liver, and arteriosclerotic cardiovascular and cerebrovascular diseases as a whole, and divide ...
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