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Duck-derived goose parvovirus artificial attenuated strain and application thereof

A technology of goose parvovirus and attenuated strains, applied in the directions of viruses, antiviral agents, virus antigen components, etc., can solve the problem that no one has reported the pathogenic mechanism of two viruses, and achieve the effect of low cost

Inactive Publication Date: 2021-03-16
HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, no one has reported the pathogenic mechanism of the two viruses

Method used

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  • Duck-derived goose parvovirus artificial attenuated strain and application thereof
  • Duck-derived goose parvovirus artificial attenuated strain and application thereof
  • Duck-derived goose parvovirus artificial attenuated strain and application thereof

Examples

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Embodiment 1

[0016] Example 1. Acquisition of Artificially Attenuated New Goose Parvovirus Attenuated Strain GPV-ZYM Strain

[0017] In 2015, a suspected duck short beak dwarf syndrome broke out in a duck farm in Cherry Valley, Shandong Province. The ducks submitted for inspection all had obvious symptoms such as short beak, long tongue, and thinness. The body of the dead duck was severely congested, and the liver, spleen, kidneys, lungs, small intestine, and pancreas all had severe bleeding, and even degeneration and necrosis. The disease material was ground and the supernatant was inoculated into duck embryos, which was identified as a new type of goose parvovirus GPV.

[0018] Previous studies have shown that the continuous alternate passage of GPV in goose embryo fibroblasts (GEF) and duck embryo fibroblasts (DEF) has an important relationship with the weakening of its virulence [9-11] . With the continuous subculture of the virus in cells, the continuous interaction between the host...

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Abstract

The invention relates to a goose parvovirus attenuated strain GPV-ZYM with the collection number of CGMCC No.15700 and application thereof to preventing ducks or gooses from being infected with duck short beak syndrome and / or gosling plague as a vaccine.

Description

technical field [0001] The present invention belongs to the biological field. Specifically, it relates to an artificially attenuated strain of duck-derived goose parvovirus and its application. Background technique [0002] In recent years, in Fujian Province of my country [1] , Shandong Province [2] , Anhui Province [3] and Fujian [4] A new type of goose parvovirus disease broke out in Muscovy ducks and Cherry Valley ducks in other provinces. After infection, the ducks showed clinical manifestations such as growth retardation, beak atrophy, and tongue protruding, commonly known as large (long) tongue disease, or short beak- dwarfism syndrome etc. The disease mostly affects meat ducks aged 10 to 30 days, with a morbidity rate of 15-100% and a mortality rate of 3-10%. The slaughter weight of diseased ducks is 20-30% lower than that of healthy ducks 5] , only 50% of normal body weight in severe cases [6] . At present, the incidence area of ​​the disease is constantly ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N7/00C12N7/08A61K39/23A61P31/20C12R1/93
CPCA61K39/12A61K2039/5254A61K2039/552A61P31/20C12N7/00C12N2750/14321C12N2750/14334C12N2750/14364Y02A50/30
Inventor 张云刘明
Owner HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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