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Novel molecular imaging probe for diagnosing multiple myeloma

A technology for multiple myeloma and molecular imaging, applied in the field of nuclear medicine and molecular imaging, can solve the problems of interfering with the diagnosis of multiple myeloma and the non-invasive and accurate diagnosis of multiple myeloma.

Active Publication Date: 2021-03-09
RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Problems solved by technology

It is worth noting that 89Zr is an osteophilic metal nuclide, and free 89Zr is easy to deposit in bone and joint tissues, thereby interfering with the diagnosis of multiple myeloma
[0006] So far, there is no noninvasive and accurate diagnosis of multiple myeloma in clinical practice, and there is no method for noninvasive evaluation of CD38 expression level in multiple myeloma plasma cells

Method used

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  • Novel molecular imaging probe for diagnosing multiple myeloma
  • Novel molecular imaging probe for diagnosing multiple myeloma
  • Novel molecular imaging probe for diagnosing multiple myeloma

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Embodiment Construction

[0058] The following describes several preferred embodiments of the present invention with reference to the accompanying drawings, so as to make the technical content clearer and easier to understand. This invention may be embodied in many different forms of embodiment, and the scope of the invention is not limited to the particular methodology, protocols, cell lines, constructs and reagents described herein, as such may vary. Unless otherwise defined, all technical and scientific terms used in this specification have the same meaning as commonly understood by one of ordinary skill in the technical field of the invention. The terms used in the description of the present invention in this specification are only for the purpose of describing specific embodiments, and are not used to limit the present invention.

[0059] At present, the examination items for the diagnosis of multiple myeloma include: blood test: blood routine, liver and kidney function (including albumin, lactate...

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Abstract

The invention discloses a novel human CD38 specific single-domain antibody and a coding gene thereof, prepares a novel molecular imaging probe for diagnosing multiple myeloma, and relates to the fieldof nuclear medicine and molecular imaging. The probe comprises a tumor targeting group, a chelating agent and radionuclide. According to the probe, the non-invasive visualization of human CD38 molecular expression is achieved, the non-invasive diagnosis of multiple myeloma and lymphoma is achieved, and the probe has the advantages of being simple in preparation process, low in cost, high in specificity, high in stability, short in imaging period, low in radiation dose, easy to convert clinically and the like.

Description

technical field [0001] The invention relates to the fields of nuclear medicine and molecular imaging, in particular to a novel molecular imaging probe for diagnosing multiple myeloma. Background technique [0002] Multiple myeloma (Multiple myeloma, MM) is a hematological malignancy derived from B cells, and currently there is no effective clinical diagnosis and treatment. CD38 is a glycoprotein highly expressed on the surface of multiple myeloma cells, and it is a good target for the diagnosis and treatment of multiple myeloma. Daratumumab, a monoclonal antibody targeting CD38, has been approved clinically for the treatment of new or relapsed multiple myeloma. Many factors affect the therapeutic efficacy of daratumumab, the most important of which is the expression level of CD38 protein on the surface of multiple myeloma cells. In addition, the dynamic change of CD38 protein expression level on the surface of multiple myeloma cells after daratumumab treatment also helps t...

Claims

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Application Information

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IPC IPC(8): C07K16/28C12N15/13C12N15/70A61K51/10A61K51/04A61K101/02A61K103/00A61K103/10
CPCC07K16/2896A61K51/1027A61K51/0482C07K2317/569
Inventor 魏伟军刘建军
Owner RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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