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High-efficiency dandruff-removing and itching-relieving shampoo and preparation method thereof

An anti-dandruff, antipruritic and shampoo technology, applied in the directions of medical preparations, hair care, and pharmaceutical formulations containing active ingredients, can solve the problems of limited bacterial inhibition, no effect, hindering the effect of antibacterial substances, etc., and achieve the effect of inhibiting enzymes Active properties, good anti-dandruff and antipruritic effect, high antibacterial activity

Pending Publication Date: 2021-02-23
云南伦扬科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inventors found that a single carbon dot has limited inhibition on bacteria, and has almost no effect on the fungus Malassezia, which may be related to the presence of sites on the target cell membrane that hinder the action of antibacterial substances

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1. Preparation of ketoconazole carbon dots: Weigh 0.4-0.6 parts of finely ground ketoconazole tablet powder and mix evenly with 0.2-0.4 parts of citric acid, add to 100 parts of ultrapure water, ultrasonic 10-20min, and transfer To a polytetrafluoroethylene reactor, heated at 200°C for 6-10 h, cooled naturally, centrifuged at 12,000 rpm for 15 min, and then filtered through a filter membrane with a pore size of 0.22 μm to obtain ketoconazole carbon dots.

[0034] 2. Preparation of kelp carbon dots: take 10-15 parts of kelp and mix with 100-150 parts of deionized water, soak and swell and beat; take the slurry and put it in a polytetrafluoroethylene-lined hydrothermal reaction kettle and heat it at a constant temperature of 180°C After 6-8 hours, cool down to room temperature naturally after the reaction is completed; pass the resulting solution through a 0.22 μm filter membrane to remove large particles of impurities, and then centrifuge at 10,000 rpm for 15-30 minutes a...

Embodiment 2

[0041] 1. Preparation of ketoconazole carbon dots: same as Example 1

[0042] 2. Preparation of kelp carbon dots: same as Example 1

[0043]3. Preparation of antifungal agent: 30 parts of ketoconazole carbon dots, 40 parts of kelp carbon dots, 1 part of clove essential oil, 2 parts of spearmint essential oil, 1 part of Span-80, 0.5 parts of TBHQ, 26 parts of deionized water Parts are stirred and mixed evenly to obtain the product.

[0044] 4. Preparation method of high-efficiency anti-dandruff and anti-itch shampoo:

[0045] (1) Add 0.2g of EDTA, 1g of quaternized hydrolyzed keratin, 3g of polyquaternium-42, and 5g of glycerol into 50g of deionized water, and stir to dissolve at room temperature;

[0046] (2) Raise the temperature to 70°C, set the stirring speed to 1000 r / min, add 10 g of sodium lauroyl glutamate, 15 g of sodium lauroyl sarcosinate, 5 g of cocoyl glucose, and lauryl amidopropyl beet 8g of alkali, stir until dissolved, and stir at constant temperature for 40...

Embodiment 3

[0049] 1. Preparation of ketoconazole carbon dots: same as Example 1

[0050] 2. Preparation of kelp carbon dots: same as Example 1

[0051] 3. Preparation of antifungal agent: 40 parts of ketoconazole carbon dots, 30 parts of kelp carbon dots, 1 part of rosemary essential oil, 2 parts of oregano essential oil, 2 parts of Tween-80, 0.4 parts of TBHQ, deionized water 25 parts were stirred and mixed uniformly to obtain the product.

[0052] 4. Preparation method of high-efficiency anti-dandruff and anti-itch shampoo:

[0053] (1) Add 0.3g of EDTA, 4g of behenyltrimethylammonium chloride, 4g of polyquaternium-42, 2g of propylene glycol, and 2g of glycerol into 60g of deionized water, and stir to dissolve at room temperature;

[0054] (2) Raise the temperature to 70°C, set the stirring speed to 1000 r / min, add 5g of sodium lauryl glucoside carboxylate, 10g of sodium lauroyl glutamate, 10g of alkyl glucoside, 5g of lauryl glucoside, coconut oil Amidopropyl betaine 3g, lauryl bet...

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Abstract

The invention discloses high-efficiency dandruff-removing and itching-relieving shampoo and a preparation method thereof. Ketoconazole tablets, citric acid and kelp are used as raw materials; ketoconazole carbon dots and kelp carbon dots are synthesized in one step through a hydrothermal method; and the synthesized carbon dots and plant essential oil are compounded into a novel antifungal agent which is used for preparing dandruff-removing and itching-relieving shampoo. The antifungal agent in the shampoo has very excellent antibacterial property on malassezia; the antibacterial effect of theantifungal agent is superior to that of a positive control drug ketoconazole; furthermore, the antifungal agent has no drug resistance; and the prepared shampoo has obvious dandruff-removing and itching-relieving effects. The synthetic raw materials of the antifungal agent are easy to obtain; the synthetic method is simple, safe and effective; and the antifungal agent is a brand-new antifungal agent.

Description

technical field [0001] The invention belongs to the technical field of daily cosmetic processing, and in particular relates to a high-efficiency anti-dandruff and anti-itch shampoo and a preparation method thereof. Background technique [0002] With the gradual improvement of the quality of life, the problem of dandruff has gradually attracted people's attention. Dandruff is a very common scalp problem worldwide. The excessive proliferation of Malassezia is an important cause of dandruff, and the chemical anti-dandruff agents commonly used in shampoo products are mostly broad-spectrum antibacterial agents. The "Safety and Technical Specifications for Cosmetics" (2015 Edition) clearly stipulates that salicylic acid, pyrithione zinc, climimazole and piroctone olamine salt are restricted ingredients, and the content shall not exceed the maximum allowable addition amount; Ketoconazole is a broad-spectrum antifungal drug, which has inhibitory and bactericidal effects on dermato...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/19A61K8/92A61Q5/00A61Q5/02A61Q17/00A61P17/04C01B32/15
CPCA61K8/19A61K8/922A61Q5/006A61Q5/02A61Q17/005A61P17/04C01B32/15A61K2800/782A61K2800/592A61K2800/5922
Inventor 焦扬万洋王秀丽
Owner 云南伦扬科技有限公司
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