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Method for alleviating tobacco or nicotine withdrawal symptoms

A nicotine and tobacco technology, applied in the fields of tobacco, pharmaceutical formulations, smokers' supplies, etc., can solve the problem that long-term withdrawal of NRTs is not very successful.

Pending Publication Date: 2021-02-05
DANSTAR FERMENT AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is well documented that long-term withdrawal from NRTs is not very successful

Method used

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  • Method for alleviating tobacco or nicotine withdrawal symptoms
  • Method for alleviating tobacco or nicotine withdrawal symptoms
  • Method for alleviating tobacco or nicotine withdrawal symptoms

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064]Example 1: The effects of Bifidobacterium bifidum, Bifidobacterium longum and Lactobacillus rhamnosus on the C. elegans model administered with nicotine and tobacco extracts.

[0065]purpose:

[0066]The purpose of this study was to evaluate the effects of Bifidobacterium bifidum, Bifidobacterium longum, Lactobacillus rhamnosus and their combinations on the behavior of C. elegans worms administered with nicotine and tobacco extracts.

[0067]Cultures of Bifidobacterium, Bifidobacterium longum and Lactobacillus rhamnosus:

[0068]The Lactobacillus rhamnosus R0011 strain was grown anaerobically in MRS medium at 37°C overnight. Bifidobacterium longum R0175 was grown anaerobically overnight in MRS medium at 37°C supplemented with 0.05% cysteine.

[0069]The overnight cultures of R0011 and R0175 strains and 1 g of the lyophilized powder of Bifidobacterium bifidum R0071 were washed once with M9 buffer, centrifuged at 4000 rpm for 10 minutes, and resuspended in 10 ml of M9 buffer. The number of liv...

Embodiment 2

[0080]Example 2: A clinical trial evaluating the effectiveness of two probiotic products in managing withdrawal symptoms related to smoking cessation during nicotine replacement therapy

[0081]purpose:

[0082]The purpose of this clinical study was to evaluate the efficacy or potential of the probiotic Bifidobacterium bifidum, Bifidobacterium longum subsp. longum, and Lactobacillus rhamnosus during nicotine replacement therapy to manage withdrawal symptoms related to smoking cessation.

[0083]Research design:

[0084]The study is a double-blind, prospective, randomized, placebo-controlled trial. The total study duration is 16 weeks. Randomization remains blind to patients and researchers.

[0085]Research group:

[0086]Seventy-five healthy participants, moderate or heavy smokers between the ages of 18 and 65 were selected for the experiment. Moderate or heavy smokers by FagerstromScore ≥5 defined, and smoke more than 10 cigarettes per day. Participants were also selected according to their willing...

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Abstract

The present disclosure provides a method for alleviating or suppressing tobacco or nicotine associated withdrawal symptoms and ease smoking cessation in individuals who wish to quit or decrease smoking tobacco or nicotine comprising the use of probiotic microorganisms.

Description

Technical field[0001]The present disclosure relates to a method for reducing tobacco or nicotine withdrawal symptoms and promoting smoking cessation. The present disclosure also relates to a composition comprising at least one bacterial strain of Lactobacillus species and an acceptable carrier for reducing or inhibiting symptoms caused by withdrawal or partial withdrawal of tobacco or nicotine. The present disclosure also relates to methods of preparing such compositions, and at least one bacterial strain of Lactobacillus species, at least one bacterial strain of Bifidobacterium species, or mixtures thereof for preparing such compositions Non-therapeutic use. The present disclosure also relates to the use of a composition comprising at least one bacterial strain of Lactobacillus species and an acceptable carrier for the preparation of a medicament for reducing or inhibiting the use of tobacco or nicotine caused by withdrawal or partial withdrawal Symptoms.Background technique[0002]T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/745A61K35/747A61P25/34
CPCA61K35/745A61K35/747A61P25/34A23L33/135A23L33/40A23V2002/00A24F47/00A23V2400/175A23V2400/517A23V2400/533
Inventor 贝伦盖尔·费兹斯蒂芬妮-安妮·吉拉尔
Owner DANSTAR FERMENT AG
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