Multistage gradient continuous crystallization method suitable for reaction crystallization process

Abstract

The invention discloses a multistage gradient continuous crystallization method suitable for a reaction crystallization process, and relates to the field of industrial crystallization process continuation and control. According to the invention, grading of an oil separation stage and a crystallization process is realized, the whole crystallization process can be effectively controlled, grading control of nucleation and crystal growth is realized, and the product quality, purity and uniformity can be improved; in addition, the synergistic regulation and control of the pH value and the temperature are further realized, and the accurate control on the product quality is realized; products with different size distribution can be obtained, and particle size grading is realized; an intermediateacid adding process is achieved through a mixer, the solution mixing performance is improved, sedimentation of crystals in a crystallizing tank is reduced through discharging of each stage of crystallizing section, temperature grading control can be achieved, and heating, dissolving and cleaning of the crystallizing tank are achieved.

Description

technical field [0001] The invention relates to the field of continuous and control of industrial crystallization process, in particular to a multi-level gradient continuous crystallization method suitable for reaction crystallization process. Background technique [0002] Reaction crystallization is one of the most common industrial crystallization methods, widely used in pharmaceutical, food fermentation, fine chemical and other industries. In many pharmaceutical processes, the crystallization process is an extremely important step. In reaction crystallization, the pH, temperature, and mixing form of reaction crystallization have a significant impact on crystallization efficiency and product quality, and also directly affect the crystal form and purity of the product. [0003] In the pharmaceutical production process, there is usually an acidification process in reaction crystallization. In the initial stage of reaction crystallization, organic molecules often exist in th...

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Problems solved by technology

The production efficiency of this process is low, and a large amount of organic solvents are used in the purification and refining process, which is likely to cause pollution to product quality and pollute the environment.

In addition, in order to reduce the impact of oil precipitation on product quality in batch production, a large number of seed crystals are usually added before the explosive nucleation of the solution. On the one hand, this method puts higher requirements on the preparation of seed crystals; The problem of low yield

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