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Pharmaceutical composition used for preventing or treating metabolism or damage-related diseases

A technology for metabolic diseases and compositions, applied in the field of biomedicine, can solve problems such as adverse reactions with severe or diverse target selectivity, different mechanisms, and unclear mechanisms, and achieve effective regulation and stabilization of body temperature and onset of effects. Fast, statistically significant effects

Active Publication Date: 2021-02-05
SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] 4) Other types, mainly including new hypoglycemic drugs including glucagon-like peptide-1 (GLP-1) analogs and dipeptidyl peptidase (DDP-IV) inhibitors, GLP-1 can be glucose-dependent It promotes insulin secretion and can inhibit the release of glucagon, and has a multi-effect therapeutic effect on type 2 diabetes, but its half-life in the body is short, only 2-6min, and it is easily absorbed by dipeptidyl peptidase (DDP) in plasma. -IV) Degradation, patients with a certain risk of thyroid tumors and a history of pancreatitis should use it with caution
However, the research time is relatively short, the mechanism is still unclear, and there are still problems such as whether the level of target selectivity will bring serious or diverse adverse reactions
[0010] Generally speaking, although there are many drugs for treating diabetes, their mechanisms are different and there are still many deficiencies. Resistance or tolerance often occurs during treatment. Therefore, providing diabetic patients with safer and more effective drugs is still an urgent problem in this field. technical issues

Method used

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  • Pharmaceutical composition used for preventing or treating metabolism or damage-related diseases
  • Pharmaceutical composition used for preventing or treating metabolism or damage-related diseases
  • Pharmaceutical composition used for preventing or treating metabolism or damage-related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Embodiment 1 diabetes model animal administration result

[0088] 1.1 Preparation of animal models

[0089] Male C57BL / 6 mice were controlled at a constant room temperature of 20-23°C, with a 12-hour light and 12-hour dark cycle, and free access to food and water. The type 1 diabetes mouse model was induced by intraperitoneal injection of 55 mg / kg streptozotocin (STZ, dissolved in citrate buffer) for 5 consecutive days, and the fasting blood glucose was measured 9 days after the last STZ injection, and the test results It proves that diabetes modeling is successful.

[0090] During the preparation of the above animal model: male C57BL / 6 mice (body weight 22-26 g) were purchased from the Guangdong Medical Experimental Animal Center. Animal experiments were carried out in strict accordance with the animal ethics guidelines and regulations of Guangzhou University of Traditional Chinese Medicine; STZ was purchased from Sigma Corporation of the United States.

[0091] 1.2...

Embodiment 2

[0115] Example 2 Lipid metabolism in renal injury model animals

[0116] 2.1 Animal model preparation

[0117] Male BALB / c mice (weight 20-25g) were purchased from the Experimental Animal Center of Southern Medical University, and the animal experiments were carried out in strict accordance with the animal ethics guidelines and regulations of Guangzhou University of Traditional Chinese Medicine. The experimental animals were controlled at a constant room temperature of 20-23° C., with 12-hour light and 12-hour dark cycles, free to eat and drink. Adriamycin nephropathy mouse model was given a one-time tail vein injection of 10.4mg / kg adriamycin (Adriamycin, dissolved in normal saline), and the normal control group was given a one-time tail vein injection of the same amount of normal saline. The test results proved that kidney damage caused model successfully. Adriamycin was purchased from Sigma, USA.

[0118] 2.2 Group administration test

[0119] After 2 weeks of administr...

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Abstract

The invention provides a pharmaceutical composition used for preventing or treating metabolism or damage-related diseases. The pharmaceutical composition comprises at least one mitochondrial uncoupling agent and at least one artemisinin compound; and the pharmaceutical composition can effectively and remarkably improve symptoms of polydipsia, polyphagia and polyuria of diabetes, reduces various metabolic indexes related to blood glucose and insulin, reduces metabolic disorders brought by insulin defects, relieves islet damage or insulin resistance, exerts a protective effect on kidneys, can effectively prevent or treat diabetic nephropathy and kidney damage related diseases, meanwhile, has certain protection and improvement effects on liver damage and lipid metabolism, can effectively adjust and stabilize the body temperature, and takes effect quickly.

Description

technical field [0001] The present invention relates to the technical field of biomedicine, in particular to a pharmaceutical composition for preventing or treating diseases related to metabolism or damage. Background technique [0002] Diabetes is a metabolic disease that seriously threatens human health and is characterized by elevated blood sugar, which can cause chronic damage to various tissues. In the past 40 years, with the aging population and changes in lifestyles in my country, the incidence of diabetes has increased. It has been increasing year by year, and has become the third chronic non-communicable disease that threatens human health after tumors and cardiovascular and cerebrovascular diseases. According to statistics from the International Diabetes Federation, in 2017, the prevalence of diabetes among people aged 20-79 in China was 10.9%, and the estimated number of patients reached 114.4 million, ranking first in the world. One of its main performance indica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/366A61K31/167A61P3/00A61P3/10A61P1/16A61P3/06A61P13/12
CPCA61K45/06A61K31/366A61K31/167A61P3/00A61P3/10A61P1/16A61P3/06A61P13/12A61K2300/00
Inventor 孙惠力韩鹏勋邵牧民翁文慈余学问
Owner SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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