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Application of dovitinib to treatment of hyperuricemia-related diseases

A high uric acid, disease technology, applied in the field of pharmacology and toxicology, can solve the problem that no one has explored the impact of uric acid excretion

Active Publication Date: 2021-02-02
薪火炙药(北京)科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its effect on uric acid excretion has not been explored

Method used

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  • Application of dovitinib to treatment of hyperuricemia-related diseases
  • Application of dovitinib to treatment of hyperuricemia-related diseases
  • Application of dovitinib to treatment of hyperuricemia-related diseases

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Experimental program
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Embodiment Construction

[0023] The inhibitory effect of dovitinib on the level of uric acid in mice was confirmed in animal experiments by the following methods.

[0024] 1. Materials and methods

[0025] 1. Reagents

[0026] UA kit (microplate method), ADA kit (microplate method), XOD kit (colorimetric method) were purchased from Nanjing Jiancheng Bioengineering Institute. PBS, purchased from Zhongke Maichen (Beijing) Technology Co., Ltd. (Lot: F31HU030). Absolute ethanol, hydrochloric acid, xylene, neutral gum, ammonia water, the above reagents were purchased from Sinopharm Chemical Reagent Co., Ltd.

[0027] 2. Experimental equipment

[0028] Electronic balance (Mettler-Toledo Instruments (Shanghai) Co., Ltd.); electric heating constant temperature water bath (Beijing Changfeng Instrument Co., Ltd.); 4 ℃ refrigerator (Qingdao Haier Co., Ltd.); -80 ℃ refrigerator (Qingdao Haier Co., Ltd. Co., Ltd.); Synergy H1 Hybrid Reader (Burton Instruments Co., Ltd., USA); high-speed refrigerated centrifuge...

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Abstract

The invention relates to a pharmaceutical application of dovitinib to treatment of hyperuricemia-related diseases, namely an application of a compound with a dovitinib basic structure parent nucleus to reduction of uric acid. Wherein the hyperuricemia-related diseases include but are not limited to hyperuricemia, hyperuricemia nephritis, hyperuricemia hypertension, hyperuricemia heart disease, gout kidney stone and gout. It is found that dovitinib has obvious functions of adenosine deaminase activity inhibition, xanthine oxidase activity inhibition and uric acid reduction and other purine metabolism inhibition effects, that is, the compound with the dovitinib basic structure parent nucleus can be used for treating the hyperuricemia-related diseases. The invention aims to provide the uric acid reducing application of dovitinib, and further relates to a medication scheme for reducing uric acid of the compound with the dovitinib basic structure parent nucleus.

Description

technical field [0001] The present invention relates to the field of pharmacology and toxicology. Specifically, the present invention relates to the medicinal use of dovitinib for treating diseases related to hyperuricemia, that is, the use of the compound having the basic structural nucleus of dovitinib in reducing uric acid. Background technique [0002] Clinically, the prevention and treatment of high uric acid-related diseases is mainly achieved by inhibiting the expression of uric acid levels and related metabolic key enzymes. Uric acid is the final product of purine metabolism in the body and is mainly excreted by the kidneys; adenosine deaminase (ADA) and xanthine oxidase (XOD) are key enzymes in purine metabolism and play a very important role in the metabolic degradation of uric acid. When the purine metabolism disorder causes the concentration of uric acid in the blood to exceed the normal value, the excess uric acid is easily deposited in soft tissues or joints, c...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K45/06A61P19/06
CPCA61K31/496A61K45/06A61P19/06A61K2300/00
Inventor 崔鹤蓉徐冰王鹏龙
Owner 薪火炙药(北京)科技有限公司
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