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Use of compound bay-876 in the preparation of medicines for treating and/or preventing liver damage

A technology of BAY-876 and compounds, applied in the field of medicine, can solve the problems of lack of specific therapeutic drugs, etc., and achieve the effects of reducing liver cell apoptosis, improving liver tissue damage, and preventing liver damage

Active Publication Date: 2021-08-31
厦门市中医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although compound glycyrrhizin, bicyclol tablets and other drugs have certain effects in clinical practice, there is still a lack of specific therapeutic drugs. Therefore, it is urgent to develop drugs for the treatment of liver damage

Method used

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  • Use of compound bay-876 in the preparation of medicines for treating and/or preventing liver damage
  • Use of compound bay-876 in the preparation of medicines for treating and/or preventing liver damage
  • Use of compound bay-876 in the preparation of medicines for treating and/or preventing liver damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] 1. Experimental materials

[0020] 1.1 Experimental drugs and reagents

[0021] BAY-876 was purchased from Selleckchem.

[0022] 1.2 Experimental animals and breeding

[0023] Male C57BL / 6 mice, 18-22g, male, provided by Shanghai Jihui Experimental Animal Breeding Co., Ltd., certificate number: 20170012002547. Breeding conditions: room temperature 20±2°C, humidity 50%±5%, alternating light and dark, moderate light, well-ventilated and clean, free to drink and eat.

[0024] 2. Method

[0025] 2.1 Modeling method of mouse model of acute liver injury

[0026] C57BL / 6 mice were fed for one week in advance, and the mouse model of acute liver injury was established by intraperitoneal injection of lipopolysaccharides (LPS) / D-galactosamine (D-Gal).

[0027] 2.2 Experimental grouping

[0028] Twenty-four C57 mice were randomly divided into 3 groups, with 8 mice in each group. They were normal control group, model group, and BAY-876 intervention group. Model group and BAY...

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PUM

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Abstract

The invention discloses the use of the compound BAY-876 in the preparation of a drug for treating and / or preventing liver damage, which can be prepared as a novel liver-protecting drug. The present invention has carried out a large number of experimental studies, using lipopolysaccharide (lipopolysaccharides, LPS) / D-galactosamine (D-Galactosamine, D-Gal) to establish an acute liver injury mouse model. The research results show that the compound BAY‑876 can significantly reduce the levels of plasma alanine aminotransferase and aspartate aminotransferase in mice with liver injury, reduce the levels of TNF‑α, IL‑6 and other inflammatory factors, significantly improve liver tissue damage, and reduce liver cell apoptosis, with significant prevention and treatment of liver damage. The present invention provides a new candidate drug BAY-876 for the treatment of liver injury.

Description

technical field [0001] The invention relates to the use of compound BAY-876 in the preparation of medicines for treating and / or preventing liver damage, and belongs to the technical field of medicine. Background technique [0002] The liver is an important metabolic organ of the human body and plays a vital physiological role. Viruses, drugs, poisons, alcohol and other causes can lead to acute liver injury, and severe cases can cause liver failure, induce multiple organ dysfunction and even death. The mechanism of acute liver injury is considered to be closely related to immune imbalance, a large number of pro-inflammatory factors secreted by activated Kupffer cells, such as tumor necrosis factor-α (tumor necrosis factor alpha, TNF-α), interleukin-6 ( The massive necrosis and apoptosis of liver cells induced by Interleukin 6 (IL-6) is the main pathogenic mechanism for the occurrence and development of the disease. [0003] Although compound glycyrrhizin, bicyclol tablets a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4709A61P1/16A61P29/00
CPCA61K31/4709A61P1/16A61P29/00
Inventor 龚先琼林芳芳吕雅云孙莹莹李珊珊陈玲张白冰
Owner 厦门市中医院
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