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An anticoagulant and anticalcification artificial heart valve material and its preparation method and application

An artificial heart valve and heart valve technology, applied in the field of biomedical materials, to achieve the effect of less chemical reagents, less damage, and stable anticoagulant effect

Active Publication Date: 2021-11-30
JILIN VENUS HAOYUE MEDICAL LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no artificial heart valve material that can well overcome the thrombogenicity of biological valves and has a good anti-calcification effect.

Method used

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  • An anticoagulant and anticalcification artificial heart valve material and its preparation method and application
  • An anticoagulant and anticalcification artificial heart valve material and its preparation method and application
  • An anticoagulant and anticalcification artificial heart valve material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Specific steps are as follows:

[0035] a. 10cm * 10cm pig heart enveloped 10cm * 10cm pig heart enveloped by 0.625 V% glutaraldehyde is immersed in 100 ml of 10V% trifluoroacetamide solution;

[0036] b. Add 10 ml of perfluornaphthylane lubricant for 24 h;

[0037] C. Save aqueous 25% isopropanol after rinsing.

Embodiment 2

[0039] Specific steps are as follows:

[0040] a. 10 cm * 10cm pig heart enveloped 10cm * 10cm pig heart envelope in 0.625 V% pentaraldehyde is immersed in 100 ml of 10V% 2,2,2-trifluoroethylamine hydrochloride solution 24 h;

[0041] b. Add 10 ml of pentafluorophenol diethyltrimethyl tetramethyl lubricant 24h;

[0042] C. Save aqueous 25% isopropanol after rinsing.

Embodiment 3

[0044] Specific steps are as follows:

[0045] a. 10 cm * 10cm pig heart enveloped 10cm * 10cm pig heart enveloped by 0.625 V% pentaraldehyde is immersed in 100 ml of 10V% 3- (whole fluorometictyl) -1,2-propylene oxide solution 24 h;

[0046] b. Add 10 ml of perfluornaphthylane lubricant for 24 h;

[0047] C. Save aqueous 25% isopropanol after rinsing.

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Abstract

The invention discloses an anticoagulant and anticalcification artificial heart valve material, a preparation method and application thereof, and belongs to the technical field of biomedical materials. The anticoagulation and anticalcification artificial heart valve material includes a biological heart valve material, a fluoride superlubricating anticoagulation coating formed by modifying the biological heart valve material with amino fluoride or epoxy fluoride, and maintaining the fluorine The lubricant in the compound super-lubricating anti-coagulation coating, by constructing a fluoride super-lubricating anti-coagulation coating on the surface of the biological heart valve material, can significantly reduce the adhesion of platelets and whole blood, greatly improve the anti-coagulation performance of the material, and effectively It overcomes the thrombogenicity of the biological valve and improves the anti-calcification performance of the material. The preparation method of the valve material is simple, and only needs simple solution immersion or vapor deposition, less damage to the animal pericardial biological valve material, and less additional or residual chemical reagents, which is conducive to maintaining a good biological phase of the material. Capacitance.

Description

Technical field [0001] The present invention belongs to the technical field of biomedical materials, and more particularly to an anticoagulant anti-calcification of artificial cardiac valve material and its preparation method and application thereof. [0002] technical background [0003] The artificial valve is a vascular implant and therefore requires good blood compatibility. For interventional bio-heart valve, the blood flow rate in the heart is fast, the blood compatibility of the bioplast is relatively good, so the probability of forming the thrombus is small, and the interventional biops is generally not required to take anticoagulation drugs for a long time. Although conventional organic valve is considered to be a good choice for anticoagulation, data analysis in recent years shows that the incidence of thrombosis associated with artificial bioplasts is high, especially with the occurrence of aortic valve replacement Biogle thrombosis is the main cause of acute or chronic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/28A61L27/36A61L27/50A61L33/00A61F2/24
CPCA61L27/28A61L27/3625A61L27/3641A61L27/3687A61L27/50A61L33/0041A61F2/24A61F2/2475A61L2400/02A61L2400/18A61L2420/02A61L2430/20
Inventor 雷洋王云兵杨立
Owner JILIN VENUS HAOYUE MEDICAL LTD
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