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A kind of sheepskin collagen peptide with dpp-iv inhibitory activity and preparation method thereof

A technology of DPP-IV and collagen peptides, applied in the field of preparation of collagen peptides with DPP-IV inhibitory activity, to achieve the effects of simple and easy to control the preparation process, improve resource utilization, and avoid environmental pollution

Active Publication Date: 2022-07-19
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there are few reports on the preparation of collagen peptides with DPP-IV inhibitory activity from sheepskin

Method used

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  • A kind of sheepskin collagen peptide with dpp-iv inhibitory activity and preparation method thereof
  • A kind of sheepskin collagen peptide with dpp-iv inhibitory activity and preparation method thereof
  • A kind of sheepskin collagen peptide with dpp-iv inhibitory activity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Raw sheepskin immersion cleaning: Rinse the depilated sheepskin with water until there is no sand in the leather water, soak it in 25 ℃ water for 3 days, and change the water every 6 hours until the sheepskin becomes soft. Cut the sheepskin into small pieces of 1×1cm, and cut off excess fat; add tap water to wash under stirring conditions for 3 hours, and change the water every 1 hour; then add deionized water to wash for 3 hours, and change the water every 1 hour, and stir at a speed of 300r / min, wash until the conductivity of the aqueous solution is less than 450μ;

[0048] Soaking and deliming: take the stirred solution, add 3% ammonium sulfate solution at a ratio of 1:3, stir and soak for 3 hours at room temperature, change the solution every 1 hour, and rinse with deionized water after deliming , measure the pH every 1h until the pH is 7.5;

[0049] Removal of impurity protein: take the pH-adjusted solution, add 1% saline solution according to the ratio of materi...

Embodiment 2

[0060] Raw sheepskin immersion cleaning: Rinse the depilated sheepskin with water until there is no sand in the leather water, soak it in 25 ℃ water for 3 days, and change the water every 6 hours until the sheepskin becomes soft. Cut the sheepskin into small pieces of 1×1cm, and cut off excess fat; add tap water to wash under stirring conditions for 3 hours, and change the water every 1 hour; then add deionized water to wash for 3 hours, and change the water every 1 hour, and stir at a speed of 300r / min, wash until the conductivity of the aqueous solution is less than 450μ;

[0061] Soaking and deliming: take the stirred solution, add 3% ammonium sulfate solution at a ratio of 1:3, stir and soak for 3 hours at room temperature, change the solution every 1 hour, and rinse with deionized water after deliming , measure the pH every 1h until the pH is 7.5;

[0062] Removal of impurity protein: take the pH-adjusted solution, add 1% saline solution according to the ratio of materi...

Embodiment 3

[0073] Raw sheepskin immersion cleaning: Rinse the depilated sheepskin with water until there is no sand in the leather water, soak it in 25 ℃ water for 3 days, and change the water every 6 hours until the sheepskin becomes soft. Cut the sheepskin into small pieces of 1×1cm, and cut off excess fat; add tap water to wash under stirring conditions for 3 hours, and change the water every 1 hour; then add deionized water to wash for 3 hours, and change the water every 1 hour, and stir at a speed of 300r / min, wash until the conductivity of the aqueous solution is less than 450μ;

[0074] Soaking and deliming: take the stirred solution, add 3% ammonium sulfate solution at a ratio of 1:3, stir and soak for 3 hours at room temperature, change the solution every 1 hour, and rinse with deionized water after deliming , measure the pH every 1h until the pH is 7.5;

[0075] Removal of impurity protein: take the pH-adjusted solution, add 1% saline solution according to the ratio of materi...

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Abstract

The invention discloses a sheepskin collagen peptide with DPP-IV inhibitory activity and a preparation method thereof, wherein the amino acid sequence of the sheepskin collagen peptide is Gly-Pro-Ala-Gly-Pro-Ile-Gly-Pro-Val. The invention provides a collagen peptide with DPP-IV inhibitory activity and a preparation method thereof, which not only realizes the comprehensive utilization of sheepskin, fully utilizes its edible quality and nutritional value, but also avoids waste of resources and environmental pollution, and has the advantages of Huge economic and social benefits.

Description

technical field [0001] The invention relates to the technical field of comprehensive utilization of sheepskin resources, in particular to a preparation method of a collagen peptide with DPP-IV inhibitory activity. Background technique [0002] Diabetes mellitus is a metabolic disease characterized by hyperglycemia and is a serious long-term disease. An estimated 4 million people died worldwide in 2017, making it one of the top ten causes of adult death. Among them, type 2 diabetes is the most common form of the disease, accounting for about 90 to 95% of all diagnosed diabetes cases. Type 2 diabetes has a variety of etiologies, and GLP-1 / DPP-IV inhibitors have become a novel approach for the treatment of type 2 diabetes. Glucagon-like peptide 1 (GLP-1) can stimulate rapid insulin release, stimulate insulin biosynthesis, inhibit β-cell apoptosis and promote β-cell differentiation in vivo. However, GLP-1 can be rapidly cleaved and inactivated by DPP-IV. Therefore, DPP-IV inh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/78C12P21/02C12P21/06C07K1/14A23L33/18
CPCC07K14/78C12P21/02C12P21/06A23L33/18A23V2002/00A23V2250/55
Inventor 刘飞于哲王贝贝陈茂深徐菲菲钟芳
Owner JIANGNAN UNIV
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