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Method for preparing pH-responsive nanofluidic diode based on nanopores modified by polyarginine and polyglutamic acid layer by layer

A technology of nanofluid and polyarginine, which is applied in the field of nanofluid, can solve problems such as the difficulty of specific structural molecules, the difficulty of entering modified substances, and the poor repeatability of nanofluid diodes, so as to avoid the effect of insufficient modification density

Pending Publication Date: 2021-01-05
NORTHWESTERN POLYTECHNICAL UNIV
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Problems solved by technology

At present, there are still many difficulties in preparing artificial nanofluidic diodes by modifying functional molecules on the inner surface of nanopores, as follows: (i) the size of the nanopores is small, and the modified substances are difficult to enter, so that the modified substances on the nanopores The density is not enough or the nanopore is blocked; (ii) the covalent modification operation is complicated, the synthesis of specific structure molecules is difficult and the cost is high; (iii) the nanopore surface is unstable after modification, and the modification is easy to fall off, which makes the repeatability of the nanofluidic diode not good

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  • Method for preparing pH-responsive nanofluidic diode based on nanopores modified by polyarginine and polyglutamic acid layer by layer
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  • Method for preparing pH-responsive nanofluidic diode based on nanopores modified by polyarginine and polyglutamic acid layer by layer

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Embodiment Construction

[0025] Now in conjunction with embodiment, accompanying drawing, the present invention will be further described:

[0026] The present invention provides a new method for preparing a nanofluid diode responsive to pH based on solid nanopores. The preparation process and working principle are as follows:

[0027] 1. Nanofluidic diodes with anion selectivity under pH action:

[0028] First, clean the PET surface, etch the nanopores by chemical etching, soak the etched nanopores in 0.5 mg / mL PLR solution for 6 hours, take them out, rinse them with secondary water, dry them, and put them in Put in an oven at 60° C. for 3 hours to obtain polyarginine-modified solid-state nanopores. The structure of the polyarginine molecule (see Figure 5 ).

[0029] The molecular structure of PLR has a large number of amino functional groups, which are positively charged in solution. Nanofluidic diodes with anion selectivity were obtained under the pH effect of PLR modified nanopores.

[0030]...

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Abstract

The invention relates to a method for preparing a pH-responsive nanofluidic diode based on nanopores modified by polyarginine and polyglutamic acid layer by layer. The inner surfaces of the nanoporesare modified by adopting a layer-by-layer polyelectrolyte electrostatic adsorption method. The method comprises the following steps of firstly, carrying out chemical etching on a PET film to obtain asingle conical polyarginine modified nanopore, and enabling the nanopore modified by the polyarginine molecule to be subjected to pH action to obtain the nanofluidic diode with anion selectivity. Polyglutamic acid molecules have a large number of carboxyl groups, polyarginine and polyglutamic acid can be modified on a polyarginine molecular layer through an electrostatic adsorption method, and nanopores modified by polyarginine and polyglutamic acid layer by layer are obtained. The nanopores modified by polyarginine and polyglutamic acid layer by layer are subjected to pH action to obtain thenanofluidic diode with cation selectivity.

Description

technical field [0001] The invention belongs to the technical field of nanofluid device preparation, and relates to a method for preparing pH response nanofluid diodes based on nanopores modified layer by layer with polyarginine and polyglutamic acid, and is a novel method for preparing pH response diodes based on solid nanopores. The method of nanofluidic diode is realized by modifying polyarginine and polyglutamic acid to the inner surface of nanopore by layer-by-layer polyelectrolyte adsorption method. Background technique [0002] Arginine, an amino acid targeted by membrane-penetrating peptides, is also abundant in protein transduction domain proteins. Arginine is a semi-(conditionally) essential amino acid for the human body and is positively charged under physiological conditions. Polyarginine (PLR) is formed by dehydration condensation of amino and carboxyl groups on multiple arginines. It is a polypeptide capable of transmembrane transport. PLR and arginine can pro...

Claims

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Application Information

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IPC IPC(8): G01N27/12B82Y40/00B82Y15/00
CPCG01N27/129G01N27/127G01N27/126B82Y40/00B82Y15/00
Inventor 安鹏荣李君谢彦博
Owner NORTHWESTERN POLYTECHNICAL UNIV
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