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Application of lomitapide in preparation of anti-tumor drugs

An anti-tumor drug, the technology of lometaxel, applied in the field of biomedicine, can solve the problems of early detection and treatment neglecting tumor prevention, and the survival rate of advanced patients is not significantly improved.

Active Publication Date: 2020-12-29
ZHENGZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, although the early screening and early diagnosis techniques of esophageal cancer have been improved, and the standard chemotherapy and radiotherapy have been used clinically for decades, the survival rate of most clinical advanced patients has not been significantly improved, suggesting that only Emphasis on early detection and treatment of tumors while ignoring tumor prevention has little effect

Method used

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  • Application of lomitapide in preparation of anti-tumor drugs
  • Application of lomitapide in preparation of anti-tumor drugs
  • Application of lomitapide in preparation of anti-tumor drugs

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Embodiment Construction

[0030] The technical solutions of the present invention will be further described in detail below in conjunction with the examples, but the protection scope of the present invention is not limited thereto.

[0031] application test

[0032] Materials and Methods

[0033] 1. Materials

[0034] 1.1 Esophageal cancer cell lines

[0035] The esophageal cancer cell line and gastric cancer cell line used in the present invention come from the Department of Pathophysiology, School of Basic Medicine, Zhengzhou University.

[0036] 1.2 Reagents

[0037] Penicillin North China Pharmaceutical Co., Ltd.

[0038] Streptomycin Shandong Lukang Pharmaceutical Co., Ltd.

[0039] RPMI-1640 Medium Israel Biological Industries Company

[0040] DMEM medium Biological Industries, Israel

[0041] 0.25% trypsin Shanghai Biyuntian Biotechnology Co., Ltd.

[0042] Serum Free Cell Freezing Medium Suzhou Xinsaimei Biotechnology Co., Ltd.

[0043] DAPI Beijing Solaibao Technology Co., Ltd.

[00...

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Abstract

The invention discloses application of lomitapide in preparation of anti-tumor drugs, and belongs to the technical field of biological medicine. Through cell proliferation experiments, the invention verifies for the first time the inhibitory effect of N-(2,2,2-trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]piperidin-1-yl]butyl)-9H-fluorene-9-carboxamide (Lometapide, CAS: 182431-12-5, molecular formula: C39H37F6N3O2, molecular weight: 693.720) in esophageal cancer cell lines (KYSE150, KYSE450) and gastric cancer (HGC27, AGS) cell lines, and can provide new ideas andbasis for drugs on the prevention and treatment of tumors in clinical research.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of lomitapide in the preparation of antitumor drugs. Background technique [0002] Globally, there are approximately 1.4 million new cases of upper gastrointestinal malignant tumors (esophageal cancer and gastric cancer) each year, and approximately 1.12 million deaths, second only to lung cancer. Among the new cases of upper gastrointestinal malignant tumors, 74.36% occurred in underdeveloped regions, and 44.60% occurred in China. Esophageal cancer is one of the most common malignant tumors in the world, ranking sixth among the most common tumors leading to cancer death, with a poor prognosis and a five-year survival rate of only 8-12%. Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are the two main histological types of esophageal cancer. ESCC is the most common subtype in developing countries, but in the United States and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4468A61P35/00A61P1/00
CPCA61K31/4468A61P35/00A61P1/00
Inventor 刘康栋董子钢周玉冰赵继敏赵四敏张静江亚南董子明
Owner ZHENGZHOU UNIV
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