Preparation method of poly-6-hydroxyhexanoate

Abstract

The invention provides a preparation method of poly6hydroxyhexanoate, which comprises the following steps: mixing poly6-hydroxyhexanoate, a catalyst and alcohol, adding the mixture into a reactor, carrying out an esterification reaction at 40-300 DEG C for 1-5h, adding a water-carrying agent after the reaction is finished, and carrying out reduced pressure distillation to remove water, thereby obtaining poly6-hydroxyhexanoate. The method has the beneficial effects that (1) the technical steps are simple, the production cost is low, and the economic benefit is high; (2) no intermediate productis produced in the technology, other product water is easy to separate and has no influence on the environment, and the process safety coefficient is high; and (3) the yield of the poly6hydroxy hexanoate is more than 90%, the production effect is good, and the product quality is high.

Description

technical field [0001] The invention belongs to the chemical industry, and in particular relates to a preparation method of poly-6-hydroxycaproic acid ester. Background technique [0002] Poly-6-hydroxyhexanoate is a linear polyester, very soft, has great stretchability, and has good biodegradability and biocompatibility, it can be used as a drug carrier and degradable surgical suture The production raw material can also be compatible with macromolecules such as polyethylene, polypropylene, polycarbonate, and polyvinyl chloride, and can be copolymerized to prepare a variety of copolymers or blends with excellent properties. It is a very useful organic material. However, at present, there are few technical materials and literatures on the synthesis and production of poly-6-hydroxycaproic acid ester. When our research group explored the process conditions of poly-6-hydroxycaproic acid alcoholysis reaction, depolymerization under different conditions obtained respectively Meth...

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Problems solved by technology

However, at present, there are few technical materials and literatures on the synthesis and production of poly-6-hydroxycaproic acid ester. When our research group explored the process conditions of poly-6-hydroxycaproic acid alcoholysis reaction, depolymerization under different conditions obtained respectively Methyl 6-hydroxycaproate, ethyl 6-hydroxycaproate, propyl 6-hydroxycaproate, ethylene glycol 6-hydroxycaproate, ε-caprolactone and oligomers, of which 6-hydroxycaproic acid The yield of ethyl ester is the highes

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