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Amisulpride tablet and preparation method thereof

An amisulpride tablet and amisulpride technology, applied in the field of medicine, can solve the problems of high production cost, complex preparation process, low production efficiency, etc., and achieve the effects of solving poor fluidity, simple preparation process and improving compliance

Pending Publication Date: 2020-12-18
JIANGSU ALPHA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

We know that the preparation process of wet granulation is complicated, the production efficiency is low, and the production cost is high

Method used

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  • Amisulpride tablet and preparation method thereof
  • Amisulpride tablet and preparation method thereof
  • Amisulpride tablet and preparation method thereof

Examples

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Effect test

preparation example Construction

[0030] And all adopt following preparation method in each embodiment, specifically comprise the following steps:

[0031] step:

[0032] S1: pulverizing amisulpride;

[0033] S2: Mix amisulpride and filler I uniformly under stirring conditions to obtain mixture A; preferably, it refers to adding amisulpride to mannitol in small amounts for multiple times.

[0034] S3: mix the mixture A obtained in S2 with the surfactant under stirring conditions, and mix uniformly to obtain a mixture B; preferably, specifically, it means first mixing the surfactant and an equal amount of the mixture A to form a mixture A', and then Then it is mixed with an equal amount of mixture A to form a mixture "A", and so on, until all the mixture A is added to obtain a mixture B;

[0035] S4: Mix the mixture B, the filler II and the flavoring agent uniformly under stirring conditions to obtain a dry powder mixture; preferably, the mixing method of equal amounts is adopted, specifically referring to mi...

Embodiment 1

[0041] Prescription composition:

[0042]

Embodiment 2

[0044] Prescription composition:

[0045]

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Abstract

The invention belongs to the technical field of medicines, particularly relates to the field of pharmacy, and more particularly relates to an amisulpride tablet and a preparation method thereof. The amisulpride tablet is prepared from the following components in percentage by mass: 39.6 to 43.8 percent of amisulpride, 0.1 to 2.0 percent of a surfactant and the balance of pharmaceutically acceptable auxiliary materials. By adding the surfactant, the in-vivo release rate of the amisulpride during use can be remarkably increased, and drug absorption is guaranteed. Meanwhile, according to the preparation method disclosed by the invention, a dry granulation process is taken as a basis, and the problem of poor raw material fluidity of the amisulpride tablet is effectively solved through materialadding sequence design; and the problems of bitter taste and the like of the amisulpride are effectively solved in a preparation process, and the medication compliance of a patient is remarkably improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to the field of pharmacy, and more specifically relates to amisulpride tablets and a preparation method thereof. Background technique [0002] Amisulpride, its chemical name is: 4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide . The structural formula is: [0003] [0004] Amisulpride is an aniline substitute psychoactive drug that can selectively interact with the D of the limbic system 2 、D 3 Binding to dopamine receptors, is an atypical antipsychotic. It is mainly used to treat acute or chronic schizophrenia with positive symptoms (such as delirium, hallucinations, cognitive impairment) and / or negative symptoms (such as slowed reaction, apathy and social decline), including negative symptoms characteristic schizophrenia. [0005] Since amisulpride is insoluble in water, controlling the release process of the drug in the body is the main me...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/20A61K47/38A61K47/26A61K31/40A61P25/18
CPCA61K9/2054A61K9/2018A61K9/2013A61K9/2095A61K31/40A61P25/18
Inventor 陈本顺石利平叶金星李大伟张维冰徐春涛程瑞华郭炳华孙伟振孟鑫刘春河何义
Owner JIANGSU ALPHA PHARM CO LTD
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