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Body fluid small molecule metabolic marker for zebra fish infected with Edwardsiella tarda and application thereof

A zebrafish and small molecule technology, applied in the field of metabolomics, can solve the problems of unclear metabolome of Edwardsiella, sluggish response of zebrafish, and drug resistance

Inactive Publication Date: 2020-12-15
HEZE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of antibiotics can effectively inhibit the infection of Edwardsiella, but the widespread use of antibiotics may lead to drug resistance, and standardizing and restricting the use of antibiotics can reduce toxic reactions (Gootz et al.2010)
[0005] The metabolome associated with regulating the immune response of zebrafish in response to Edwardsiella infection is currently largely unknown

Method used

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  • Body fluid small molecule metabolic marker for zebra fish infected with Edwardsiella tarda and application thereof
  • Body fluid small molecule metabolic marker for zebra fish infected with Edwardsiella tarda and application thereof
  • Body fluid small molecule metabolic marker for zebra fish infected with Edwardsiella tarda and application thereof

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Embodiment Construction

[0030] The present invention will be further described below with reference to the examples. However, the scope of the invention is not limited to the following examples. Those skilled in the art will appreciate that various variations and modifications can be made to the present invention without departing from the spirit and scope of the invention.

[0031] The present invention generally and / or specifically described the materials and test methods used in the test. While many of the materials and operation methods used to achieve the objectives of the invention are well known in the art, the present invention is still described in detail herein.

[0032] The instruments, reagents, materials, etc., which are involved in the following examples are not particularly illustrated, all of which are conventional instruments, reagents, materials, etc. in the prior art, can be obtained through a regular business pathway. The experimental method, detecting method, etc. according to the ...

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PUM

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Abstract

The invention discloses a body fluid small molecule metabolic marker for zebra fish infected with Edwardsiella tarda. The marker is at least one of arginine, proline, valine, leucine, isoleucine and Cadaverine, preferably proline and valine. The invention also discloses an application of the body fluid small molecule metabolic marker of zebra fish infected with Edwardsiella tarda in improving theimmunity of zebra fish responding to Edwardsiella tarda infection, and an application in regulating and controlling zebra fish arginine proline metabolic pathways and valine leucine isoleucine biosynthetic metabolic pathways. It is found through experiments that proline and valine play an important role when zebra fish responds to Edwardsiella tarda infection, play an extremely important role in zebra fish innate immune response and can be used for research of metabolome functions. The marker has important reference value for researching metabonomics related to zebra fish response to Edwardsiella tarda infection immune response.

Description

Technical field [0001] The present invention relates to zebrafish infection Edwardsiella tarda humoral markers and small molecule metabolites belonging to the technical field application ,, metabolomics. Background technique [0002] Metabolomics (metabonomics / metabolomics) is thought to follow study of genomics and proteomics, for all metabolites in vivo quantitative analysis and research to find a way relative relationship metabolites physiological and pathological changes, biological systems are component. The research objects are large molecular weight less than 1,000 small molecules. Group refers to a metabolic or biological cells in a particular physiological period all low molecular weight metabolites, metabolomics is a particular organism or cell simultaneously all qualitative and quantitative analysis of low molecular weight metabolites in a particular physiological period of a new discipline, which is based on the group index analysis-based, high-throughput detection ...

Claims

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Application Information

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IPC IPC(8): G01N33/68A61K31/401A61K31/198A61P37/04A61P31/04A23L33/175
CPCA23V2002/00A61K31/198A61K31/401A23L33/175A61P31/04A61P37/04G01N33/6893G01N2800/7095A23V2200/324
Inventor 张海丽朱刚钱礼尧张梦琪王慧琪
Owner HEZE UNIV
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