Application of prometrone as proinflammatory cytokine inhibitor

A cytokine and primidone technology, applied in the field of medicine, can solve problems such as no effective solution, and achieve the effect of reducing mortality and improving the situation of hypothermia

Inactive Publication Date: 2020-12-15
YICHANG NO 1 PEOPLES HOSPITAL PEOPLES HOSPITAL OF CHINA THREE GORGES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no effective clinical treatment for similar diseases. Generally, hormone therapy, antibiotics or antiviral therapy, and symptomatic and supportive treatment are used.

Method used

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  • Application of prometrone as proinflammatory cytokine inhibitor
  • Application of prometrone as proinflammatory cytokine inhibitor
  • Application of prometrone as proinflammatory cytokine inhibitor

Examples

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Embodiment Construction

[0033] The present invention will be further described below in conjunction with the accompanying drawings.

[0034] This example discloses the application of primidone as an inhibitor of pro-inflammatory cytokines.

[0035] Use of primidone for inhibition of pro-inflammatory cytokines.

[0036] Pro-inflammatory cytokines include TNF-α and / or IL-1β.

[0037] Use of primidone as a TNF-α inhibitor.

[0038] Use of primidone as an IL-1β inhibitor.

[0039] Use of primidone as an inhibitor of TNF-α and IL-1β.

[0040] Use of primidone in the treatment of systemic inflammatory response syndrome.

[0041] Use of primidone as a therapeutic agent for systemic inflammatory response syndrome.

[0042] Use of primidone in the treatment of sepsis.

[0043] Use of primidone as a therapeutic agent for sepsis.

[0044] Use of primidone in the treatment of pneumonia.

[0045] Use of primidone as a therapeutic agent for pneumonia.

[0046] Application of primidone in the treatment of ...

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Abstract

The invention belongs to the technical field of medicines, and discloses application of prometrone as a proinflammatory cytokine inhibitor, application of prometrone in inhibiting proinflammatory cytokines, application of prometrone in treating systemic inflammatory response syndrome, sepsis, pneumonia and neocoronary pneumonia, wherein the proinflammatory cytokines comprise TNF-alpha and / or IL-1beta. According to the application, a mouse model of SIRS is induced by adopting TNF-alpha caudal vein injection, prometrone can remarkably reduce the death rate of SIRS and improve the body temperature reduction condition of SIRS, so that SIRS and related diseases with the same pathogenesis as SIRS are treated, and as a result, prometrone can be used as the proinflammatory cytokine inhibitor, andhas very important significance for treating related diseases such as systemic inflammatory response syndrome, sepsis, pneumonia and neocoronary pneumonia.

Description

technical field [0001] The invention relates to the application of primidone as an inhibitor of pro-inflammatory cytokines, belonging to the technical field of medicine. Background technique [0002] Systemic inflammatory response syndrome (systemic inflammatory response syndrome, SIRS) is triggered by a series of sterile inflammation, which is caused by severe damage to the body to infectious or non-infectious factors such as infection, trauma, burn, operation and ischemia-reperfusion The systemic non-specific inflammatory response of the body eventually leads to a group of clinical symptoms of the body's uncontrolled inflammatory response, including fever, tachycardia, shortness of breath, and increased peripheral blood leukocytes. Its main pathological process includes a "cytokine storm" in which overproduction of pro-inflammatory cytokines such as TNF-α and IL-1β triggers vascular dysfunction and organ damage. "Cytokine storm" occurs in chemotherapy, H1N1 infection, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/513A61P29/00A61P31/14A61P11/00A61P31/16A61P31/04
CPCA61K31/513A61P29/00A61P31/14A61P11/00A61P31/16A61P31/04
Inventor 查运红胡昕倩何小燕李敏魏钧牟彦祝国锋王君赵海龙黄明余雅婕张宏冰
Owner YICHANG NO 1 PEOPLES HOSPITAL PEOPLES HOSPITAL OF CHINA THREE GORGES UNIV
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