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Microcapsule-filled sodium alginate-based hydrogel and preparation method thereof

A sodium alginate and microcapsule technology is applied in the field of microcapsule-filled sodium alginate-based hydrogel and its preparation, which can solve the problems of poor stability and low loading rate of hydrophobic functional substances, and achieves good structural stability, The method is simple and easy to implement, and the effect of controlled release is good.

Active Publication Date: 2020-12-08
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the strong hydrophilicity of sodium alginate, there are some defects in the structure of a single sodium alginate hydrogel, such as low loading rate of hydrophobic functional substances and poor stability, etc., which limit the development of sodium alginate to a certain extent. Applications of hydrogel-based

Method used

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  • Microcapsule-filled sodium alginate-based hydrogel and preparation method thereof
  • Microcapsule-filled sodium alginate-based hydrogel and preparation method thereof
  • Microcapsule-filled sodium alginate-based hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Step 1. Preparation of zein-based microcapsules:

[0028] Weigh 0.2 parts by mass of zein and add it to 10.0 parts by mass of 85% ethanol aqueous solution, then add 0.01 parts by mass of thymol and 0.01 parts by mass of polyoxyethylene lauryl ether, and stir for 2 h to prepare a mixed solution ; Then add 20 parts by mass of ultrapure water to the mixed system, and then remove the ethanol in the mixed system by rotary evaporation to obtain a zein-based microcapsule emulsion.

[0029] Step 2, preparing sodium alginate solution:

[0030] Weigh 0.1 parts by mass of sodium alginate into 50 parts by mass of water, stir for 6 hours in a water bath at 40°C until completely dissolved, and obtain a sodium alginate solution;

[0031] Step 3, preparation of microcapsule-filled sodium alginate-based hydrogel:

[0032] Take 0.1 mass part of zein microcapsule emulsion and add it to 1.0 mass part of sodium alginate solution, adjust the pH of the system to 6.5 with 0.1 mol / L NaOH and ...

Embodiment 2

[0034] Step 1. Preparation of zein-based microcapsules:

[0035] Weighed 0.2 parts by mass of zein and added it to 10.0 parts by mass of 85% ethanol aqueous solution, then added 0.05 parts by mass of mugwort essence and 0.06 parts by mass of Pluronic F127, and stirred for 2 h to prepare a mixed solution; 22 parts by mass of ultrapure water were added to the mixed system, and then the ethanol in the mixed system was removed by rotary evaporation to prepare a zein-based microcapsule emulsion.

[0036] Step 2, preparing sodium alginate solution:

[0037] Weigh 0.5 parts by mass of sodium alginate into 50 parts by mass of water, stir for 6 h in a water bath at 48°C until completely dissolved, and obtain a sodium alginate solution;

[0038] Step 3, preparation of microcapsule-filled sodium alginate-based hydrogel:

[0039] Get 0.5 parts by mass of zein microcapsule emulsion and add it to 1.0 parts by mass of sodium alginate solution, adjust the pH of the system to 6.5 with 0.1 mo...

Embodiment 3

[0041] Step 1. Preparation of zein-based microcapsules:

[0042] Weigh 0.2 parts by mass of zein and add it to 10.0 parts by mass of 85% ethanol aqueous solution, then add 0.10 parts by mass of eugenol and 0.10 parts by mass of Pluronic F127, and stir for 2 h to prepare a mixed solution; 25 parts by mass of ultrapure water was added to the mixed system, and then the ethanol in the mixed system was removed by rotary evaporation to prepare a zein-based microcapsule emulsion.

[0043] Step 2, preparing sodium alginate solution:

[0044] Weigh 1.0 parts by mass of sodium alginate and add it to 50 parts by mass of water, and stir for 6 hours in a water bath at 56°C until completely dissolved to obtain a sodium alginate solution;

[0045] Step 3, preparation of microcapsule-filled sodium alginate-based hydrogel:

[0046]Take 1.0 parts by mass of zein microcapsule emulsion and add it to 1.0 parts by mass of sodium alginate solution, adjust the pH of the system to 6.5 with 0.1 mol / L...

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Abstract

The invention discloses microcapsule-filled sodium alginate-based hydrogel and a preparation method thereof. The method comprises the following steps: dissolving zein with an ethanol solution to obtain a dissolving solution, adding a hydrophobic functional substance and a surfactant into the zein solution, and preparing to acquire a zein-based microcapsule emulsion by adopting an anti-solvent method; meanwhile, adding sodium alginate into water, heating and stirring under a water bath condition to obtain a sodium alginate solution, adjusting the pH value of the system, sequentially adding thezein-based microcapsule emulsion and the CaCl2 solution, stirring, and aging for a period of time to obtain the microcapsule-filled sodium alginate-based hydrogel. The prepared composite material hasthe characteristics of hydrogel and microcapsules, has the advantages of being good in structural stability, capable of loading various hydrophobic functional substances, good in controlled release property and the like, and has wide application prospects in the fields of biological medicine, food processing and the like.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and in particular relates to a microcapsule-filled sodium alginate-based hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a kind of extremely hydrophilic three-dimensional network structure gel, which swells rapidly in water and can maintain a large volume of water without dissolving in this swollen state. All water-soluble or hydrophilic polymers can form hydrogels through certain chemical cross-linking or physical cross-linking. These polymers can be divided into two categories according to their sources, natural and synthetic. Natural hydrophilic polymers mainly include polypeptides (collagen, poly-L-lysine, poly-L-glutamic acid, etc.) and polysaccharides (cellulose, chitosan, sodium alginate, etc.). Among them, sodium alginate is a natural anionic polysaccharide extracted from brown algae. Its molecules contain a large amount of -COO-. Under ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/04C08L89/00C08K3/16
CPCC08J3/075C08J3/246C08J2305/04C08J2489/00C08K2003/162
Inventor 徐群娜白忠薛彭楚奇
Owner SHAANXI UNIV OF SCI & TECH
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