A kind of in situ intimal regeneration vascular stent covering and preparation method thereof

Abstract

The invention discloses a vascular stent covering for in situ intima regeneration and a preparation method thereof. Bombyx mori silk is divided into two groups, one group is a group of twisted and combined silk threads, and the other group is a group of monofilaments, which are dissolved in lithium bromide after degumming Neutral salt solution to prepare silk fibroin solution, then pour the silk fibroin solution into a dialysis bag with a certain molecular weight cut-off, dialyze to obtain the purified silk fibroin aqueous solution, and then use a rotary evaporator to concentrate the silk fibroin to a suitable concentration. quality score. Add a hydrophilic flexible molecular cross-linking agent to the silk fibroin aqueous solution, mix evenly and remove air bubbles to obtain a modified silk fibroin solution, then knit the monofilament into a tubular structure with a braiding machine, and coat it on the silk fibroin tubular structure Each layer of coating is rotated and air-dried in the circumferential direction under low-temperature hot air, and the coating is controlled to be a uniform molecular layer, so as to obtain a stent graft with in situ intimal regeneration. The membrane has excellent toughness and induces in situ regeneration of the vascular intima that regulates the balance of the blood system.

Description

A kind of vascular stent covering for in situ intimal regeneration and preparation method thereof technical field The present invention relates to the technical field of vascular stent coating preparation, be specifically related to a kind of vascular stent of in-situ intimal regeneration Film and method of making the same. Background technique With the improvement of living standards and the acceleration of the aging process, the incidence of cardiovascular and cerebrovascular diseases is increasing significantly year by year. Cardiovascular and cerebrovascular diseases such as embolism, vascular stenosis, and vascular aneurysm are a serious threat to human health, and have become the mortality rate of human beings. highest cause. With the development of medicine, minimally invasive endovascular isolation has gradually become a variety of arterial lesions due to the small surgical trauma. The main treatment method of vascular stent graft is the main body of endovas...

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Problems solved by technology

The covering materials currently used clinically do not have excellent histocompatibility, and long-term postoperative restenosis is prone to occur, and complications such as slippage also occur