Millimeter ball catalyst for one-step synthesis of chiral alcohol and chiral ester from acetophenone

Abstract

The invention belongs to the field of catalytic materials, and particularly relates to a millimeter ball catalyst for one-step synthesis of chiral alcohol and chiral ester from acetophenone. Metal andenzyme are assembled in the catalyst, the particle size is 0.9-3.0 mm, and the mechanical strength is as high as 3.0-15.0 N. A preparation method comprises the following steps of adding silicon oxidenanoparticles loaded with metal nanometer Pd and silicon oxide nanoparticles loaded with candida antarctica lipase B into deionized water, and performing uniform stirring and mixing to obtain a two-component silicon oxide mixed solution; continuously dripping the double-component silicon oxide mixed solution on tiled super-hydrophobic silicon oxide powder, and performing slow rolling to form a droplet millimeter ball which has a silicon oxide hydrophobic shell; collecting the droplet millimeter ball, and slowly drying the droplet millimeter ball; and finally, performing drip washing with acetone, and performing vacuum drying to obtain the millimeter ball for encapsulating the metal and enzyme dual-catalyst. The catalyst can be directly loaded into a fixed bed reactor to synthesize the chiral alcohol and the chiral ester from the acetophenone in one step.

Description

technical field [0001] The invention belongs to the field of catalytic materials, in particular to a millimeter sphere catalyst for one-step synthesis of chiral alcohols and chiral esters from acetophenone. Background technique [0002] One-step tandem synthesis of chiral products is an important way to realize green and efficient processes, because there is no need to separate intermediate products, it can overcome equilibrium limitations, improve reaction efficiency, and reduce by-products. In one-step tandem catalytic reactions, multifunctional catalysts with different activities usually require dual-cascade and multi-component processes, metal-enzyme catalysts are a new class of catalysts composed of enzymes and metal nanoparticles, which have the functions of chemical and biochemical catalysts, Can be used in chemical enzyme cascade reaction. However, each catalytic active center requires different media. Metals tend to be high temperature and organic solvents, while e...

AI Technical Summary

Problems solved by technology

However, the existing systems mainly rely on mechanical mixing of two catalysts, or the preparation of metal-enzyme hybrid catalysts. These methods are difficult to achieve efficient coupling and continuous reaction.

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