Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for carrying out secondary reinforcement on chloromethylated resin by utilizing cross-linking reaction

A technology of cross-linking reaction and chloromethylation, which is applied in the field of hemoperfusion adsorption resin, can solve the problems that the specific surface area and adsorption performance cannot meet the use requirements, the structure of the macroporous resin is not compact enough, and the threat to production safety, etc., and achieve structural Compactness, high strength, and the effect of reducing production costs

Pending Publication Date: 2020-12-01
昌果生物医药科技河北有限公司
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Through the analysis of the preparation method of the existing macroporous adsorption resin, it can be seen that the production process of the existing macroporous resin needs to use raw materials such as highly toxic chloromethyl ether, and it needs to be completed in multiple steps. The chloromethyl ether used in the production is highly toxic Substances have a certain threat to production safety, and the structure of the macroporous resin produced by the existing technology is not compact enough, the strength is low, and the specific surface area and adsorption performance cannot meet the gradually increasing use requirements

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A method for secondary strengthening of chloromethylated resins by cross-linking reaction, prepared according to the following steps:

[0023] (1) Synthesis of white balls: Add 1000ml of water to a 2000ml three-neck bottle and heat up to 55°C, add 5g of polyvinyl alcohol and 30g of sodium chloride and stir for half an hour as the water phase. Add 100g of divinylbenzene with a purity of 80%, 50g of liquid paraffin, 150g of toluene, and 0.5% of BPO into the beaker as the oil phase. Slowly add the oil phase to the water phase, start stirring and control the speed until the oil phase has a suitable particle size, and stir at a constant speed. The temperature was raised from 55°C to 75°C at a rate of 5°C / 10 minutes. After the resin is set for 2 hours, continue to heat up from 75°C to 85°C at a speed of 5°C / 10 minutes, keep it warm for 4 hours, continue to heat it up from 85°C to 95°C at a speed of 5°C / 10 minutes, and take it out after 6 hours of heat preservation. Wash awa...

Embodiment 2

[0027] (1) Synthesis of white balls: Add 1000ml of water to a 2000ml three-neck bottle and heat up to 55°C, add 5g of polyvinyl alcohol and 30g of sodium chloride and stir for half an hour as the water phase. Add 75g of divinylbenzene with a purity of 80%, 50g of liquid paraffin, 100g of toluene, and 1% of BPO into the beaker as the oil phase. Slowly add the oil phase to the water phase, start stirring and control the speed until the oil phase has a suitable particle size, and stir at a constant speed. The temperature was raised from 55°C to 75°C at a rate of 5°C / 10 minutes. After the resin is set for 2 hours, continue to heat up from 75°C to 85°C at a speed of 5°C / 10 minutes, keep it warm for 4 hours, continue to heat it up from 85°C to 95°C at a speed of 5°C / 10 minutes, and take it out after 6 hours of heat preservation. Wash away the polyvinyl alcohol on the surface of the resin with warm water, extract the porogen by Soxhlet extractor with acetone for 8 hours, wash with w...

Embodiment 3

[0031] (1) Synthesis of white balls: Add 1000ml of water to a 2000ml three-neck bottle and heat up to 55°C, add 5g of polyvinyl alcohol and 30g of sodium chloride and stir for half an hour as the water phase. Add 125g of divinylbenzene with a purity of 80%, 50g of liquid paraffin, 100g of toluene, and 1% of BPO into the beaker as the oil phase. Slowly add the oil phase to the water phase, start stirring and control the speed until the oil phase has a suitable particle size, and stir at a constant speed. The temperature was raised from 55°C to 75°C at a rate of 5°C / 10 minutes. After the resin is set for 2 hours, continue to heat up from 75°C to 85°C at a speed of 5°C / 10 minutes, keep it warm for 4 hours, continue to heat it up from 85°C to 95°C at a speed of 5°C / 10 minutes, and take it out after 6 hours of heat preservation. Wash away the polyvinyl alcohol on the surface of the resin with warm water, extract the porogen by Soxhlet extractor with acetone for 8 hours, wash with ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Specific surface areaaaaaaaaaaa
Login to View More

Abstract

The invention discloses a method for carrying out secondary reinforcement on chloromethylated resin by utilizing a cross-linking reaction. Formaldehyde and hydrochloric acid are used as chlorinating agents for a methylation reaction, and meanwhile, dichloroethane is used for carrying out a secondary cross-linking reaction on chloromethyl-containing resin, so production cost is greatly reduced andproduction is safer; the macroporous resin having been subjected to methylation and secondary cross-linking is more compact in structure and higher in strength, has a specific surface area of up to 1000 m<2> / g, shows better adsorption performance and is mainly used as an adsorbent in a hemoperfutor; and when the resin is applied to bilirubin adsorption, an adsorption amount is higher than 0.8 [mu]mol / ml.

Description

technical field [0001] The invention relates to the technical field of hemoperfusion device adsorption resin, in particular to a method for secondary strengthening of chloromethylated resin by cross-linking reaction. Background technique [0002] A large number of studies have shown that hemoperfusion can effectively treat hyperbilirubinosis. The most popular adsorbent is activated carbon, but its adsorption selectivity is poor, and particles are prone to fall off and cause blood vessel blockage. After capsule treatment, although it has basically Solve the problem of particle shedding, but the cost of activated carbon is high, which increases the economic burden of patients. In recent years, many researchers have devoted themselves to the research and development of polymer adsorbents. These materials have wide applicability and low cost in hemoperfusion devices. The adsorption structure can be designed in a targeted manner. At present, there are hour A macroporous resins, h...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08F112/36C08F8/24C08L25/02C08K5/02C08J3/24C08J9/28
CPCC08F8/24C08F112/36C08J3/24C08J9/28C08J2325/02C08K5/02
Inventor 李宗倍毛瑞琪
Owner 昌果生物医药科技河北有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com