Preparation method of disposable polyethersulfone liquid medicine membrane

Abstract

The invention discloses a preparation method of a disposable polyethersulfone liquid medicine membrane, belonging to the technical field of biomedical polymer materials. The method disclosed by the invention comprises the following steps of: step 1, mixing and dissolving polyethersulfone with an organic solvent at 40-80 DEG C, adding a pore-forming agent, carrying out sufficient stirring and dissolving, filtering out insoluble substances, and carrying out vacuum defoaming to obtain a membrane casting solution, wherein the membrane casting solution comprises, in parts by weight, 15-20 parts ofpolyethersulfone, 45-60 parts of the organic solvent and 1-10 parts of the pore-forming agent; and step 2, casting the membrane casting solution on a support body, and conducting knifing by using a scraper to obtain a primary membrane. According to the preparation method, hydrophilic bonds can be better grafted to a base membrane of the polyethersulfone micro-filtration membrane, so the hydrophilicity of the polyethersulfone membrane is greatly improved, and the flux of liquid is improved; and due to the existence of charges, the anti-pollution capability of the filtration membrane is improved, the service life of the filtration membrane is prolonged, use cost is reduced, and good economic benefits are obtained.

Description

technical field [0001] The invention belongs to the technical field of biomedical polymer materials, in particular to a preparation method of a disposable polyethersulfone liquid membrane. Background technique [0002] Infusion therapy can supplement the nutrients, water, electrolytes, etc. necessary for the human body, and plays a very important role in clinical treatment. However, ordinary infusion sets can only filter out particles with a diameter of more than 20 microns in the liquid medicine, and have no interception effect on particles with a diameter of 0.2 microns to 10 microns. The insoluble particles in the drug are very harmful to the human body, may cause blood vessel injury, and are prone to thrombosis, fat embolism, air embolism, etc., and even form thrombophlebitis, which can block microcirculation and cause different degrees of necrosis or necrosis of human tissues or organs. damage. Therefore, the research on filter membranes in medical liquid filters, esp...

AI Technical Summary

Problems solved by technology

[0003] At present, the microfiltration membranes produced in the market and used in the filtration of medical clinical infusion terminals mainly include melt-blown polypropylene non-woven fabrics, polyethersulfone microfiltration membranes produced by phase inversion method, nuclear pore membranes, nylon membranes, etc. There are some defects in the membranes. Melt-blown polypropylene non-woven fabrics have long fibers and are easy to fall off. The product is hydrophobic and needs to be hydrophilically modified in the later stage. The hydrophilic groups are easy to lose, so that the liquid flow does not meet the requirements. Polyethersulfone The microfiltration membrane is also modified to achieve the hydrophilic effect, and the durability is poor. The thickness of the nuclear pore membrane is between 0.02mm-0.03mm, the firmness is poor, and it is not easy to assemble. The nylon membrane is acid-resistant and not alkali-resistant. Under, the pore size will change