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System for analyzing mass difference of mitochondria or lysosome and method thereof

A technology of quality difference and lysosome, applied in the field of difference analysis, can solve the problem that the results cannot be directly compared

Active Publication Date: 2020-10-30
UB BIOTECHNOLOGY ZHEJIANG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the existing process of using flow cytometry to detect the quality changes of mitochondria and lysosomes, there will be background noise problems; and the existing detection methods only evaluate the mitochondria or lysosomes of different samples through a single experiment Quality differences, in order to study the reasons for the differences in samples, there is a problem that the results obtained this time cannot be directly compared with the next experiment

Method used

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  • System for analyzing mass difference of mitochondria or lysosome and method thereof
  • System for analyzing mass difference of mitochondria or lysosome and method thereof
  • System for analyzing mass difference of mitochondria or lysosome and method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] This embodiment provides a system for analyzing the difference in mass of mitochondria or lysosomes, such as figure 1 shown, including:

[0046] The detection module 11 is used to detect peripheral blood through an in vitro detection kit to obtain the original data of mitochondria or lysosomes;

[0047] The processing module 12 is used to process the obtained raw data of mitochondria or lysosomes based on dimensionality reduction algorithms and instrument calibration tools to obtain damage values ​​corresponding to mitochondria or lysosomes;

[0048] The comparison module 13 is configured to compare the obtained damage value with a preset threshold value to obtain the analysis result of mitochondrial or lysosome mass difference.

[0049] In the detection module 11, the peripheral blood is detected by an in vitro detection kit to obtain the original data of mitochondria or lysosomes.

[0050] In this example, the in vitro detection kit relies on a special mitochondrial...

Embodiment 2

[0101] This embodiment provides a method for analyzing the difference in mass of mitochondria or lysosomes, such as image 3 shown, including:

[0102] S11. Using an in vitro detection kit to detect peripheral blood to obtain the original data of mitochondria or lysosomes;

[0103] S12. Process the obtained raw data of mitochondria or lysosomes based on the dimensionality reduction algorithm and instrument calibration tools to obtain damage values ​​corresponding to mitochondria or lysosomes;

[0104] S13. Comparing the obtained damage value with a preset threshold value to obtain the analysis result of mitochondrial or lysosome mass difference.

[0105] It should be noted that the method for analyzing the difference in mass of mitochondria or lysosomes provided in this example is similar to that of Example 1, and will not be repeated here.

[0106] Compared with prior art, the beneficial effect of the present invention is:

[0107] 1. Through the collection of specific sam...

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Abstract

The invention discloses a system and a method for analyzing mass difference of mitochondria or lysosome, and relates to a system for analyzing mass difference of mitochondria or lysosome, which comprises a detection module for detecting peripheral blood through an in-vitro detection kit to obtain original data of mitochondria or lysosome; a processing module used for processing the obtained original data of the mitochondria or lysosome based on a dimension reduction algorithm and an instrument correction tool to obtain a numerical value corresponding to the mitochondria or lysosome; and a comparison module used for comparing the obtained numerical value with a preset threshold value to obtain a mitochondria or lysosome quality difference analysis result. According to the invention, the detection process of background noise is reduced, and the use cost and the operation complexity of the detection method are reduced.

Description

technical field [0001] The present invention relates to the technical field of difference analysis, in particular to a system and method for analyzing the quality difference of mitochondria or lysosomes. Background technique [0002] Mitochondria and lysosomes, as subcellular organelles, have very limited quality detection methods. Since most subcellular organelles are in the process of dynamic development and are always in the process of division and fusion, it is generally difficult to detect changes in their functions. Usually, the quality of mitochondria Directly related to function, such as literature: "Federico A, Cardaioli E, Da Pozzo P, Formichi P, Gallus GN, Radi E. Mitochondria, oxidative stress and neurodegeneration. J Neurol Sci. 2012;322(1-2):254-262 . doi:10.1016 / j.jns.2012.05.030", "Youle RJ, Bliek AM van der. Mitochondrial Fission, Fusion, and Stress. Science (New York, NY). 2012;337(6098):1062. doi: 10.1126 / science.1219855". [0003] The conventional metho...

Claims

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Application Information

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IPC IPC(8): C12Q1/02G16C20/20G16H50/20
CPCG01N33/5005G16H50/20G16C20/20
Inventor 李国平
Owner UB BIOTECHNOLOGY ZHEJIANG CO LTD
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