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Injectable hydrogel dressing with pH response as well as preparation method and application thereof

A technology for injecting water and gel, applied in pharmaceutical formulations, pharmaceutical science, drug delivery, etc., can solve problems such as insufficient hemostasis and healing promotion properties, poor adhesion of hydrogels, and difficulty in application.

Pending Publication Date: 2020-10-30
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the shortcomings of the above-mentioned prior art, the object of the present invention is to provide a pH-responsive injectable hydrogel dressing and its preparation method and application to solve the problem of poor adhesion of the existing hydrogel in an acidic environment, Insufficient hemostasis and healing-promoting properties make it difficult to apply to the technical problems in the fields of gastric hemostasis and wound healing

Method used

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  • Injectable hydrogel dressing with pH response as well as preparation method and application thereof
  • Injectable hydrogel dressing with pH response as well as preparation method and application thereof
  • Injectable hydrogel dressing with pH response as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0059] 1) Preparation of double-bonded amino acid derivatives, acryloyl 6-aminocaproic acid (AA):

[0060] 19.8 g of 6-aminocaproic acid was added to 120 ml of deionized water, and 6.6 g of sodium hydroxide was added to the solution. Stir vigorously in an ice bath until the 6-aminocaproic acid dissolves. 13.35 mL of acryloyl chloride was added to 22.5 mL of tetrahydrofuran solution, and then the acryloyl chloride solution was added dropwise into the aminocaproic acid solution. Adjust and maintain the pH at 7.5-7.8, and react for 24 hours. After the reaction was completed, it was extracted three times with ethyl acetate (100 mL / time). Collect and combine the organic phases. The aqueous phase was acidified to pH 3, and then extracted with ethyl acetate 3 to 5 times (100 mL / time). All the above-mentioned extracted organic phases were collected and combined, dried with sodium sulfate for 18 hours, and then suction filtered using a Buchner funnel. Rotary evaporation is then ca...

Embodiment 2

[0066] Dilute the concentration of AA in step 3 to 146 mg / mL, and add 50 μL of 100 mg / mL AA-NHS solution to it, which is prepared with dimethyl sulfoxide. Other conditions were the same as in Example 1 to obtain an AA / AA-NHS5 hydrogel dressing.

Embodiment 3

[0068] Dilute the concentration of AA in step 3 to 138 mg / mL, and add 50 μL of 200 mg / mL AA-NHS solution to it, and other conditions are the same as in Example 2 to obtain AA / AA-NHS10 hydrogel dressing.

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Abstract

The invention discloses an injectable hydrogel dressing with pH response as well as a preparation method and application thereof. A polymer monomer and a tissue cross-linking agent monomer are subjected to free radical polymerization reaction to prepare the injectable hydrogel dressing with pH response. A double-bonded amino acid or a double-bonded amino acid derivative is subjected to an esterification reaction with -OH on NHS (N-hydroxysuccinimide) through -COOH of the double-bonded amino acid or the double-bonded amino acid derivative, and the tissue cross-linking agent monomer is prepared.The preparation method is simple to operate; the used raw materials are easy to obtain and low in price; and meanwhile, the prepared hydrogel dressing has good adhesiveness, pH responsiveness, injectability, self-healing performance and hemostatic performance, can effectively promote stomach hemostasis and wound healing after endoscopic therapy, and has huge application value in the fields of stomach hemostasis and wound healing.

Description

technical field [0001] The invention belongs to the technical field of degradable biomedical materials, and relates to a pH-responsive injectable hydrogel dressing and its preparation method and application. Background technique [0002] Gastrointestinal cancer is one of the most common malignancies worldwide. Despite advances in surgical treatment, chemotherapy, and immunotherapy for gastrointestinal cancer in recent decades, gastrointestinal cancer still constitutes the leading cause of death in patients with related cancers due to its aggressive and metastatic nature (A. Pourshams, S.G.Sepanlou, K.S.Ikuta, C. Bisignano, S.Safiri, G.Roshandel, M.Sharif, M.Khatibian, C.Fitzmaurice, M.R. Nixon, The Lancet Gastroenterology & Hepatology 2019, 4,934; A.Etemadi, S.Safiri, S.G.Sepanlou, K. Ikuta, C. Bisignano, R. Shakeri, M. Amani, C. Fitzmaurice, M. Nixon, N. Abbasi, The Lancet Gastroenterology & Hepatology 2020, 5, 42.). Endoscopic mucosal resection (EMR) and endoscopic submu...

Claims

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Application Information

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IPC IPC(8): C08F220/06C08F220/36C08F222/38C08J3/075A61L26/00C08L33/02
CPCA61L26/0019A61L26/0066A61L26/008A61L2300/41A61L2300/412A61L2400/04A61L2400/06C08F220/06C08J3/075C08J2333/02C08F220/36C08F222/385C08L33/02
Inventor 郭保林初大可何刚贺佳辉
Owner XI AN JIAOTONG UNIV
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