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Degradable composite nanofiber three-dimensional material and application thereof in tissue repair

A technology of composite nanofibers and nanofibers, applied in medical science, pharmaceutical formulations, prostheses, etc., can solve problems such as poor hydrophilicity and unfavorable cell adhesion, and achieve low dissolution rate and good biocompatibility

Inactive Publication Date: 2020-10-30
嘉兴市爵拓科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, synthetic polymers have poor hydrophilicity, which is not conducive to cell adhesion.

Method used

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  • Degradable composite nanofiber three-dimensional material and application thereof in tissue repair
  • Degradable composite nanofiber three-dimensional material and application thereof in tissue repair
  • Degradable composite nanofiber three-dimensional material and application thereof in tissue repair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A method for preparing a degradable composite nanofiber three-dimensional material,

[0035](1) preparation of dopamine graft: dissolving geniposidic acid in water, adjusting pH to 5.5, adding catalyst 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and N -Hydroxysuccinimide, add dopamine hydrochloride after dissolving, react at 25°C for 24 hours under nitrogen atmosphere, remove catalyst and unreacted monomers by dialysis, freeze-dry to obtain dopamine grafts; add geniposidic acid The amount is 3wt% of the aqueous solution, the addition amount of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride is 3wt% of the aqueous solution, the addition amount of N-hydroxysuccinimide is the aqueous solution 4wt% of the aqueous solution, the addition of dopamine hydrochloride is 2wt% of the aqueous solution.

[0036] (2) Preparation of silk fibroin nanofiber solution: add sodium bicarbonate to boiling water, add silk after dissolving, and stir for 20 minutes, th...

Embodiment 2

[0039] A method for preparing a degradable composite nanofiber three-dimensional material,

[0040] (1) preparation of dopamine graft: dissolving geniposidic acid in water, adjusting pH to 5.5, adding catalyst 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and N -Hydroxysuccinimide, add dopamine hydrochloride after dissolving, react at 25°C for 24 hours under nitrogen atmosphere, remove catalyst and unreacted monomers by dialysis, freeze-dry to obtain dopamine grafts; add geniposidic acid The amount is 3wt% of the aqueous solution, the addition amount of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride is 3wt% of the aqueous solution, the addition amount of N-hydroxysuccinimide is the aqueous solution 4wt% of the aqueous solution, the addition of dopamine hydrochloride is 2wt% of the aqueous solution.

[0041] (2) Preparation of silk fibroin nanofiber solution: add sodium bicarbonate to boiling water, add silk after dissolving, and stir for 20 minutes, t...

Embodiment 3

[0044] A method for preparing a degradable composite nanofiber three-dimensional material,

[0045] (1) preparation of dopamine graft: dissolving geniposidic acid in water, adjusting pH to 5.5, adding catalyst 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and N -Hydroxysuccinimide, add dopamine hydrochloride after dissolving, react at 25°C for 24 hours under nitrogen atmosphere, remove catalyst and unreacted monomers by dialysis, freeze-dry to obtain dopamine grafts; add geniposidic acid The amount is 3wt% of the aqueous solution, the addition amount of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride is 3wt% of the aqueous solution, the addition amount of N-hydroxysuccinimide is the aqueous solution 4wt% of the aqueous solution, the addition of dopamine hydrochloride is 2wt% of the aqueous solution.

[0046] (2) Preparation of silk fibroin nanofiber solution: add sodium bicarbonate to boiling water, add silk after dissolving, and stir for 20 minutes, t...

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Abstract

The invention discloses a degradable composite nanofiber three-dimensional material and application thereof in tissue repair, and belongs to the technical field of degradable materials. The compositenanofiber three-dimensional material is prepared from a dopamine graft, and the dopamine graft adopts geniposidic acid to graft dopamine. The dopamine graft is adopted to prepare the composite nanofiber three-dimensional material so that the total amount of cell DNA on the surface of the composite nanofiber three-dimensional material is increased by at least 42.86%, and the highest dissolution loss rate of the composite nanofiber three-dimensional material is only 11%. The composite nanofiber three-dimensional material can be used for tissue repair materials and is stable, porous, good in biocompatibility and low in dissolution loss rate.

Description

technical field [0001] The invention belongs to the technical field of degradable materials, and in particular relates to a degradable composite nanofiber three-dimensional material and its application in tissue repair. Background technique [0002] The loss and dysfunction of tissues and organs is one of the major hazards to human health and the leading cause of human disease and death. Over the years, great efforts have been made to improve organ transplantation techniques, but organ and tissue shortages remain a major problem. This also promotes more research work on artificial repair materials that can be used to replace natural organs and tissues. The concept of Tissue Engineering was first formally proposed by the National Science Foundation of the United States in 1987. Its definition is to use the principles and technologies of life science and engineering to construct and cultivate living tissues and develop biological substitutes for repair or reconstruction. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/50A61L27/56A61L27/58C08J9/00C08L89/00
CPCA61L27/222A61L27/227A61L27/50A61L27/56A61L27/58A61L2400/12C08J9/0061C08J2389/00C08J2489/00C08L89/00
Inventor 不公告发明人
Owner 嘉兴市爵拓科技有限公司
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