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Skin repair film and preparation method thereof

A skin repair and carboxymethyl cellulose technology, which is applied in medical science, bandages, etc., can solve problems such as no reports of carboxymethyl cellulose and bioactive glass composite skin repair film, and achieve good biocompatibility And the effect of degradability, good biocompatibility, and easy absorption of exudate

Active Publication Date: 2020-10-30
上海硅健生物材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report on the application of carboxymethyl cellulose and bioactive glass composite materials in skin repair membranes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A novel skin repair film is prepared according to the method of the present invention. Weigh 3g of carboxymethylcellulose, add it to 100ml of purified water, heat to 60°C and stir until it dissolves completely. Under the condition of mechanical stirring 500r / min, 3g of bioactive glass was slowly added, stirred for 10min, poured into the mold, and then freeze-dried (pre-freezing for 2 hours, freeze-drying for 16h) to obtain a new skin repair film.

Embodiment 2

[0035] A novel skin repair film is prepared according to the method of the present invention. Take carboxymethyl cellulose 2g, add carboxymethyl cellulose to 100ml purified water, be heated to 60 ℃ and stir until it dissolves completely. Slowly add 1g of bioactive glass under the condition of mechanical stirring 600r / min, stir for 10min, and pour into the mold. Dry in an oven at 60° for 4 hours, then freeze-dry (pre-freeze for 4 hours, freeze-dry for 10 hours), and then cut according to the required size to obtain a thinner new skin repair film.

Embodiment 3

[0037] A novel skin repair film is prepared according to the method of the present invention. Weigh 1g of carboxymethylcellulose, add it to 100ml of purified water, heat to 60°C and stir until it dissolves completely. Under the condition of mechanical stirring 800r / min, 2g of bioactive glass was slowly added, stirred for 30min, poured into the mold, and then freeze-dried (pre-freezing for 1 hour, freeze-drying for 20h) to obtain a new skin repair film.

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Abstract

The invention discloses a skin repair film and a preparation method thereof. The skin repair film is prepared from carboxymethyl cellulose and bioactive glass. A preparation method specifically comprises the following steps: (1) adding carboxymethyl cellulose into water, and carrying out stirring until carboxymethyl cellulose is fully dissolved; (2) slowly adding bioactive glass under the condition of mechanical stirring after dissolving of carboxymethyl cellulose; and (3) conducting drying and forming, and carrying out injection molding and freeze drying to obtain the skin repair film. The skin repair film combines the advantages of carboxymethyl cellulose and bioactive glass, is convenient to use clinically, has a spongy porous structure and can absorb ulcer exudate; all the raw materials of the skin repair film are nonirritant to the human body and good in biocompatibility; toxic residues caused by chemical cross-linking agents are avoided; and the skin repair film can be applied tosurface skin repair and digestive tract repair, such as inner wall repair of the stomach, the duodenum and other digestive tracts.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a skin repair film; in addition, the invention also relates to a preparation method of the skin repair film. Background technique [0002] The skin of the human body is a barrier to maintain the stability of the internal environment of the human body and prevent the invasion of microorganisms. If the skin is damaged in a large area, it will cause many local or even systemic problems, such as increased metabolism, excessive loss of water and protein, immune system disorders, etc., and even life-threatening. If the wound is covered with an appropriate dressing, it can effectively reduce the severity of hypermetabolism in the patient's body, relieve pain, prevent bacterial infection, and accelerate wound healing. At present, there are tens of millions of skin trauma patients in the world, especially with the aging society and the rising incidence of diabetes in my country, the t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0023A61L26/0085A61L26/0066A61L2300/112A61L2300/412C08L1/26
Inventor 刘玮杨成然常江忻鼎度
Owner 上海硅健生物材料有限公司
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