Application of ceramide in preparation of kit for evaluating adverse event risks of heart failure patients
A technology of ceramide and heart failure, applied in the field of application of ceramide in the preparation of a kit for evaluating the risk of adverse events in patients with heart failure
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[0061] After 255 patients with heart failure (HF patients) were followed up for an average of 568 days, 45 died and 4 underwent heart transplantation. Outcome events were all-cause death and heart transplantation. Higher Cer(d18:1 / 16:0 / d18:1 / 24:0) ratio levels in heart failure patients were significantly associated with all-cause mortality and cardiac transplantation events (log rank<0.005).
[0062] like figure 1 As shown, the levels of different types of ceramides were compared between age-sex-matched healthy people (n=40) and HF patients (n=40). Among them, Cer(d18:1 / 16:0), Cer(d18:1 / 18:0), Cer(d18:1 / 20:0), and Cer(d18:1 / 24:1) had significant differences.
[0063] like figure 2 Shown is the scatter diagram of the differences in various ceramide levels in patients with end-stage heart failure, in which Cer(d18:1 / 16:0) was higher in the group with adverse events (P<0.005), and Cer(d18:1 / 16:0) was higher in the group with adverse events (P<0.005), 24:0) were lower (P<0.05...
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