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A kind of medicine with neuroprotective effect and its application

A kind of drug and cardiac neurosis technology, applied in the field of medicine, to achieve the effect of good curative effect and obvious curative effect

Active Publication Date: 2022-04-15
MUDANJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mechanism and use of these compounds in the treatment of nervous tension and other diseases have not been reported yet

Method used

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  • A kind of medicine with neuroprotective effect and its application
  • A kind of medicine with neuroprotective effect and its application
  • A kind of medicine with neuroprotective effect and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Preparation of Cerase - 3'- Nothic Acid Ester and Its Granules

[0029] The compound of formula (I) of the present invention has a named churrosin-3'-no meal acid ester:

[0030]

[0031] Molecular weight: 704.630; CAS number: 28543-07-9; Source: Chengdu Puri Technology Development Co., Ltd. \ Chengdu Turbanization Pure Biotechnology Co., Ltd., purity ≥98%;

[0032] Ceramicin-3'-prepared for mealic acid granules

[0033] Prescription: Ewa-3'-no companion 300g

[0034] Accessories: β-cyclodextrin, gamma-cyclodextrin, microcrystalline cellulose, low substituted hydroxypropylene, pacidezone K30 and water. The amount of β-cyclodextrin is used as a tea-3'-no food of the meal, the gamma-cyclodextrin is used as a tea-3'-no meal of 0.4 times, the microcrystalline cellulose is used as tea.黄素 -3'-no food 1 times, low substituted hydroxypropylene cellulose is a tea-3'-no meal of 0.17 times, the polyvilone K30 is the amount of tea-3'- There were 0.17 times the weight of the...

Embodiment 2

[0039] Example 2 Toxicology experiment of compounds of formula (I)

[0040] 1, toxic acute experiment

[0041] (1) Oral administration

[0042]Use Kunming mice, weight 20g ± 2g, female and female. The tea -3'-no food glycoside granules were prepared by 20% water-mixing solution, and the mice were given a mouse 3 times a day, 0.3ml each time, with a total amount of 180mg / kg, and continuously observed for 7 days. No death, no poison side reactive;

[0043] (2) Injection

[0044] Use Kunming mice, weight 20g ± 2g, female and female. Tea-3'-no food is used as 2% injection. Injection is administered, 0.4ml per only. LD50 (IP) = 25.76 + 6.35 g / kg, LD50 (IV) = 18.55 + 4.68 g / kg were measured.

[0045] 2, long-term toxicity test

[0046] With SD rats, the weight was 200 ± 20g, and the female is half a half, a total of 180. Gas given gantry. The tea-3'-did not have a 20% water mixing solution, and the dose was 1 mg / kg, 5 mg / kg, 20 mg / kg, 60 mg / kg, respectively, for six months...

Embodiment 3

[0049] Example 3 The main pharmacological effects of Embumin-3'-did not addic acid effect were observed by animal test.

[0050] I. Effects of Embassium-3'-Nothic Acid Granules on Animal Autonomous Activity

[0051] 1. Animals group: 30 mice in Kunming, 20 ~ 22g weighing, female and half;

[0052] 2. Preparation of the subject: 30g The particulate agent and 100 ml of water obtained are uniformly mixed with a mixed solution (4 ° C) in the conventional refrigerator, which is taken at room temperature before the test administration, and at room temperature before the test. That is, the granule is subject to the test article;

[0053] 3, animal grouping, according to the random principle, randomly divided into 3 groups, namely blank control group, contrast group (chloropropatoxazine) and test group (granule subject to the present embodiment), each Group 10.

[0054] 4, animal administration pathway and dose: mode of administration: Animal is administered orally (gastrointestinal); the...

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Abstract

The invention provides a kind of medicine with neuroprotective effect and application thereof. The medicine is theaflavin-3'-gallate, and its structure is shown in formula (I). Described compound of formula (I) has obvious effect in terms of depressive neurosis, and the antidepressant effect of theaflavin-3'-gallate is mainly by increasing the content of 5-HT and DA in the brain, improving the synaptic cleft nerve. The concentration of the transmitter can be achieved, which can obviously relieve and treat nervous symptoms. The theaflavin-3'-gallate of the present invention also has a good curative effect in the aspect of cardiac neurosis.

Description

Technical field [0001] The present invention belongs to the field of medical technology, and more particularly to a drug having neuroprotective effects and its applications, more particularly to a kind of tea-3'-no feed acid derivative thereof and its application. Background technique [0002] No food acid is also known as "diplimipoxic acid", "sour acid". "3,4,5-trihydroxybenzoic acid". Molecular formula C 7 Hide 6 O 5 . It is widely used in plants such as chain, large leaves, hawthorn and other plants, and a wide range of polyphenolic compounds in nature have extensive applications in food, biology, medicine, and chemical. Embumin-3'-no meal acid ester is a major monomer in black tea in tea, is also one of the main indicators of the color and flavor of black tea tea. Existing literatures show that eating vanoids have a variety of pharmacological and health function, such as lower blood fat, antioxidant, anti-aging. [0003] In terms of biological activity: no food acid has a va...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/353A61P25/00A61P25/24
CPCA61K31/353A61P25/00A61P25/24
Inventor 冯莹刘颖于成龙任春娜杨雪琦郭玲
Owner MUDANJIANG MEDICAL UNIV
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