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Novel coronavirus particle quantitative detection method based on nano plasma resonance

A quantitative detection method and plasmon resonance technology, which can be used in measurement devices, instruments, material analysis by optical means, etc., can solve the problem of high detection cost

Pending Publication Date: 2020-10-23
LIANGZHUN SHANGHAI MEDICAL EQUIP CO LTD
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Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a quantitative detection method for novel coronavirus particles (SARS-CoV-2) based on a nano-plasmon resonance sensor chip to solve the problem of commercial Biacore SPR biological The problem of high detection cost of sensor system and improved virus particle detection method

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  • Novel coronavirus particle quantitative detection method based on nano plasma resonance
  • Novel coronavirus particle quantitative detection method based on nano plasma resonance
  • Novel coronavirus particle quantitative detection method based on nano plasma resonance

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Embodiment Construction

[0029] In order to make the content of the present invention clearer and easier to understand, the content of the present invention will be described in detail below in conjunction with specific embodiments and accompanying drawings.

[0030] figure 1 Schematically shows a flow chart of the steps of the method for quantitative detection of novel coronavirus particles based on a nano-plasmon resonance sensor chip according to a preferred embodiment of the present invention, figure 2 Schematically showing a schematic diagram of a quantitative detection method for novel coronavirus particles based on a nano-plasmon resonance sensor chip according to a preferred embodiment of the present invention, image 3 A schematic diagram of the principle of the method for quantitative detection of novel coronavirus particles based on a nano-plasmon resonance sensor chip according to a preferred embodiment of the present invention is schematically shown.

[0031] Such as figure 1 , figur...

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Abstract

The invention discloses a novel coronavirus particle quantitative detection method based on nano plasma resonance. The novel coronavirus particle quantitative detection method comprises the followingsteps that plasma photon resonance coupling effect equipment and nano gold particles are prepared for amplifying a detection signal; the surface of a nano plasma resonance sensing chip is modified with an SARS-COV-2 capture antibody, and gold nanoparticles are labeled with an SARS-COV-2 labeled antibody; SARS-CoV-2 virus particle samples are added with different titers into the labeled nano gold particles; a mixed solution is added into the pore plate to be detected, and capture of the SARS-CoV-2 virus particle and labeled gold nanoparticle compound is completed. The method is advantaged in that by detecting the change curve of the absorbance difference value along with time under the specific wavelength before and after sample adding, SARS-CoV-2 virus particle quantitative detection is achieved.

Description

technical field [0001] The invention relates to the field of detection technology, in particular to a method for quantitative detection of novel coronavirus particles based on nano-plasmon resonance. Background technique [0002] The measurement of molecular interaction kinetics is increasingly important in drug discovery, genetic screening, and clinical diagnosis, as dynamically combined information can improve understanding of diseases and can provide new ideas for treatment. Surface plasmon resonance (SPR) sensors, such as the commercial Biacore SPR biosensor system, enable real-time monitoring of kinetic biomolecular interactions, label-free and immune to extensive background. Since the commercial Biacore SPR biosensor system is a traditional SPR device, it requires special equipment and operation by a dedicated person, making the purchase or use of the biosensor system require a lot of money. [0003] The new coronavirus is the seventh coronavirus discovered so far tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/569G01N33/543G01N33/532G01N21/552
CPCG01N33/56983G01N33/543G01N33/532G01N21/554G01N2333/165
Inventor 黄丽萍刘钢许浩胡文君
Owner LIANGZHUN SHANGHAI MEDICAL EQUIP CO LTD
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