Novel traditional Chinese medicine sustained-release injection, preparation method and application to treatment of mycoplasma synovialis of poultry

Abstract

The invention relates to a novel traditional Chinese medicine sustained-release injection, a preparation method and an application to treatment of mycoplasma synovialis of poultry. Each 100 g of the injection comprises 0.01-2.0 g of visnagin, 0.01-5.0 g of forsythol, 10.0-40.0 g of tween-80, 0.5-10.0 g of poloxamer 407, 0.1-8.0 g of glyceryl behenate, 1.0-16.0 g of ethyl oleate, 5.0-10.0 g of 2-propanediol and the balance of deionized water. The invention further discloses a preparation method of the novel traditional Chinese medicine sustained-release injection. The method has high process operability and is beneficial to production transformation. The sustained-release injection is bicontinuous phase emulsion, the main component is a traditional Chinese medicine extract, and the problemof food safety due to drug residues can be solved; after injection, drugs can be slowly released locally in tissue, a long-acting effect is achieved, the injection administration frequency reduced, stress of poultry is reduced, and the market prospect is wide.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, and in particular relates to a novel sustained-release injection of traditional Chinese medicine, a preparation method thereof and an application in treating poultry synovial bursa mycoplasma disease. Background technique [0002] Mycoplasma synovialis is a common poultry infectious disease caused by mycoplasma synovialum infection. Infected poultry mainly manifests joint inflammation, swelling, and a large amount of effusion. Although it will not directly cause animal death, it will affect other animals. behaviors such as walking and standing. The poultry with this disease has decreased activity, low spirits, dry and dull coat color, likes to lie alone in a corner, and is easy to be trampled by other birds in the same cage and die. Due to inconvenient walking, the disease indirectly affects behaviors such as feeding and drinking. The body will gradually weaken due to long-term nutr...

AI Technical Summary

Problems solved by technology

Due to the inconvenience of walking, the disease indirectly affects the behavior of eating and drinking water. The body will gradually weaken due to long-term nutritional deficiency, growth and development will be hindered, production performance will decline, and eventually it will die of exhaustion, which will bring huge economic losses to the farm.

[0003] At present, the drugs for the treatment of mycoplasma synovial bursae are mainly chemical antibiotics, such as enrofloxacin, tilmicosin, doxycycline, riscomycin, tiamulin fumarate, etc. The killing ability is strong, but the following three problems will appear in clinical use: First, these drugs belong to antibiotics, which are suitable for the treatment of young poultry and young poultry. Once the poultry enters the laying period, the use of antibiotics will remain in the eggs. Affect food safety, so chemical antibiotics are not suitable for poultry during the laying period; second, these antibiotics are absorbed and utilized throughout the body after use, but the lesions are in the joints, and the concentration of the actual drug effect in the joints is low, resulting in drug bioavailability The third is that the treatment of mycoplasma disease itself needs a long process, generally at least one week of clinical medication can gradually recover, in order to maintain blood drug concentration, continuous medication is required within a week, and chemical drugs have toxic side effects , continuous drug administration is very harmful to the body, and if it is administered by injection, the behavior of catching animals and injecting drugs every day will cause great stress to animals, seriously affect production performance, and it is time-consuming and laborious for farm workers

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