Rat non-alcoholic fatty liver model feed as well as preparation method and application thereof

A non-alcoholic and fatty liver technology, which is applied in the field of rat non-alcoholic fatty liver model feed and its preparation, can solve the problem of being unable to use diet to feed rats, and achieve the effect of shortening the time for model building

Pending Publication Date: 2020-10-02
常州鼠一鼠二生物科技有限公司
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the deficiencies of the above-mentioned prior art, the present invention provides a method for preparing rat non-alcoholic fatty liver model feed, the purpose is to solve the problem that the existing diet cannot be used to feed rats, and the preparation is related to the pathogenesis of human non-alcoholic fatty liver disease. Technical Issues with a Comparable Rat Model of Nonalcoholic Fatty Liver Disease

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Rat non-alcoholic fatty liver model feed as well as preparation method and application thereof
  • Rat non-alcoholic fatty liver model feed as well as preparation method and application thereof
  • Rat non-alcoholic fatty liver model feed as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0022] The preparation method of the rat nonalcoholic fatty liver model feed provided by the present embodiment, the specific technical scheme is as follows:

[0023] The preparation method of rat nonalcoholic fatty liver model feed comprises the steps:

[0024] S1, accurately weigh the raw materials shown in Table 1, and mix 23.31% casein, 0.35% cystine, 8.48% corn starch, 11.65% maltodextrin, 20.14% sucrose, 5.83% cellulose, 5.24% compound minerals, 1.17% compound vitamins, 0.23% choline bitartrate, 1.25% cholesterol and 0.2% mass ratio thiouracil are mixed to obtain mixed powder;

[0025] S2, adding 2.91% soybean oil and 20.68% lard (fat with a heat ratio of 40%) to the mixed powder in step S1 for stirring to obtain an oil mixture;

[0026] S3, adding water to the oil mixture in step S2, stirring and mixing, and granulating by a granulator to obtain soft pellet feed with a particle diameter of 10-15mm. The particle diameter of the soft pellets in this embodiment is about 1...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the technical field of experimental animals, and particularly relates to a preparation method of rat non-alcoholic fatty liver model feed. The method comprises the following steps of accurately weighing basal feed and 2% cholesterol to be mixed; adding grease with the calorie ratio of 40% to be stirred; adding water to be stirred and mixed, and performing granulation through a granulator to obtain soft granulated feed; performing drying at a low temperature to obtain the rat non-alcoholic fatty liver model feed. The invention also provides the rat non-alcoholic fatty liver model feed and an application thereof. Modeling can be completed after a rat is fed with the rat non-alcoholic fatty liver model feed for 8-10 weeks, so that the modeling time is shortened, and an animal model similar to human non-alcoholic fatty liver disease pathogenesis is successfully copied. Besides, the rat is fed with the pure feed, gavage is not needed, animal ethics are met, the ratnon-alcoholic fatty liver model can be obtained, various symptoms of human non-alcoholic fatty liver diseases are simulated, and a theoretical basis is provided for research of human related diseases.

Description

technical field [0001] The invention belongs to the technical field of experimental animals, and in particular relates to a rat nonalcoholic fatty liver model feed and a preparation method and application thereof. Background technique [0002] Nonalcoholic fatty liver disease is a clinicopathological syndrome characterized by steatosis and fat accumulation in liver parenchymal cells without a history of excessive alcohol consumption or daily alcohol intake. The disease spectrum varies with the progress of the disease, including four different pathological stages of simple fatty liver, steatohepatitis, cirrhosis and hepatocellular carcinoma. It can occur in men and women of different races and age groups, and the incidence rate of men and women is almost the same, especially in obese and diabetic patients. In patients with liver disease, after excluding other liver diseases, it is caused by approximately. It has become one of the most important public health problems in the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A23K50/50A23K20/147A23K20/142A23K20/163A23K20/20A23K20/174A23K20/105A23K20/168A23K20/158A23K40/10A01K67/02
CPCA23K50/50A23K20/147A23K20/142A23K20/163A23K20/20A23K20/174A23K20/105A23K20/168A23K20/158A23K40/10A01K67/02
Inventor 姜海善
Owner 常州鼠一鼠二生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap