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Quaternized chitin antipathogenic microorganism spray as well as preparation method and application thereof

An anti-pathogenic microorganism, salinized carapace technology, applied in the fields of botanical equipment and methods, biocides, antiviral agents, etc. Get practical application and other issues to achieve the effect of reducing the risk of secondary pollution, protecting the skin and mucous membranes, and curbing the spread of infection

Pending Publication Date: 2020-09-29
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In some special but common application scenarios, chitin-based antibacterial materials with excellent performance cannot be practically applied
Masks and protective clothing themselves do not have the ability to kill pathogenic microorganisms such as bacteria and viruses. The pathogenic microorganisms remaining on discarded masks and protective clothing are very important potential sources of infection. If discarded masks and protective clothing are not treated medically, they will be Discarded, it is easy to cause serious secondary pollution
At the same time, a large number of medical devices also require the treatment of anti-pathogenic microbial materials to block nosocomial infections

Method used

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  • Quaternized chitin antipathogenic microorganism spray as well as preparation method and application thereof
  • Quaternized chitin antipathogenic microorganism spray as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Prepare quaternary ammonium salted chitin anti-pathogenic microorganism spray according to the following steps:

[0037] (1) Prepare raw materials according to the following components: 20 g of quaternized chitin; 350 g of glycerin; 30 g of dexpanthenol;

[0038] (2) First add 8L of medical sterile pure water to the agitator after washing and drying;

[0039](3) Add the quaternized chitin into the stirrer, and continue to stir for 1 hour until the quaternized chitin is fully dissolved;

[0040] (4) After filtering to remove solid residual impurities in the solution, dialyze with sterile pure water to completely remove chloride ions;

[0041] (5) Continue to stir the fully dissolved quaternized chitin solution obtained after dialysis and slowly add glycerin, and stir for 10-20 minutes until the solution is evenly mixed;

[0042] (6) Add dexpanthenol, then set the volume to 10L, and keep stirring until completely mixed;

[0043] (7) Sent to the next step for sub-packag...

Embodiment 2

[0047] Prepare quaternary ammonium salted chitin anti-pathogenic microorganism spray according to the following steps:

[0048] (1) Prepare raw materials according to the following components: 50g of quaternized chitin; 200g of glycerin; 150g of dexpanthenol;

[0049] (2) First add 8L of medical sterile pure water to the agitator after washing and drying;

[0050] (3) Add the quaternized chitin into the stirrer, and continue to stir for 1 hour until the quaternized chitin is fully dissolved;

[0051] (4) After filtering to remove solid residual impurities in the solution, dialyze with sterile pure water to completely remove chloride ions;

[0052] (5) Continue to stir the fully dissolved quaternized chitin solution obtained after dialysis and slowly add glycerin, and stir for 10-20 minutes until the solution is evenly mixed;

[0053] (6) Add dexpanthenol, then set the volume to 10L, and keep stirring until completely mixed;

[0054] (7) Sent to the next step for sub-packagi...

Embodiment 3

[0058] Prepare quaternary ammonium salted chitin anti-pathogenic microorganism spray according to the following steps:

[0059] (1) Prepare raw materials according to the following components: quaternized chitin 80g; glycerin 150g; dexpanthenol 350g;

[0060] (2) First add 8L of medical sterile pure water to the agitator after washing and drying;

[0061] (3) Add the quaternized chitin into the stirrer, and continue to stir for 1 hour until the quaternized chitin is fully dissolved;

[0062] (4) After filtering to remove solid residual impurities in the solution, dialyze with sterile pure water to completely remove chloride ions;

[0063] (5) Continue to stir the fully dissolved quaternized chitin solution obtained after dialysis and slowly add glycerin, and stir for 10-20 minutes until the solution is evenly mixed;

[0064] (6) Add dexpanthenol, then set the volume to 10L, and keep stirring until completely mixed;

[0065] (7) Sent to the next step for sub-packaging. After...

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Abstract

The invention provides a quaternized chitin antipathogenic microorganism spray as well as a preparation method and application thereof. The quaternized chitin antipathogenic microorganism spray comprises the following components: the concentration of quaternized chitin is 0.2-1.0 wt%, the concentration of glycerin is 0.5-3.5wt%, the concentration of dexpanthenol is 0.3-4.0 wt%, and the balance ismedical sterile pure water, wherein the deacetylation degree of the quaternary ammonium salt chitin is 7.4 to 60.5 percent, and the substitution degree of quaternary ammonium salt is 0.28 to 0.82. Thequaternized chitin antipathogenic microorganism spray provided by the invention has the characteristics of excellent biological safety, no toxicity, no immunogenicity and biodegradability, and also has multiple effects including broad-spectrum efficient antibacterial and antiviral properties and wound healing promotion; and the preparation method of spray is simple and practical and beneficial toindustrial production.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a quaternary ammonium salted chitin anti-pathogenic microorganism spray, its preparation method and application. Background technique [0002] Chitin is a crystalline polysaccharide composed of β-(1→4)-2-acetylamino-D-glucose, which is widely found in the exoskeleton of aquatic animals such as shrimp and crab, the cuticle of invertebrates, green algae, fungi and yeast In the cell wall of bacteria, it is a natural polymer that is second only to cellulose in terms of accumulation on the earth. Chitosan is a product obtained from the deacetylation reaction of chitin. Not only the solubility is further improved, but the positively charged amino groups on its surface also enhance the antibacterial properties. Chitin and chitosan are derived from organisms and are renewable natural polymer materials with good biocompatibility, biodegradability, non-toxic and non-immunog...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K31/722A61K47/18A61K47/10A61P31/04A61P31/14A61P31/10A61P17/02A01N25/06A01N43/16A01P1/00A01P3/00
CPCA01N25/06A01N43/16A61K9/0014A61K9/12A61K31/722A61K47/10A61K47/18A61P17/02A61P31/04A61P31/10A61P31/14Y02A50/30
Inventor 王彦峰夏天卞晓恩陈祖涵
Owner WUHAN UNIV
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