A device and method for rapid generation of core-shell droplets based on surface acoustic wave microfluidics

Abstract

A device and method for rapid generation of core-shell droplets based on surface acoustic wave microfluidics, including a droplet control system and a core-shell droplet generation system; the droplet control system includes an interdigital transducer, and the upper part of the interdigital transducer Bonded with a voice-activated PDMS microchannel, arc-shaped electrodes are made on the interdigital transducer, and the arc-shaped electrode cooperates with the acoustic-activated PDMS microchannel. The acoustic-activated PDMS microchannel is equipped with a dispersed phase inlet joint, and the lower part of the interdigital transducer is bonded. There is a core-shell droplet generation system; the core-shell droplet generation system is formed by bonding the top layer of PDMS, the second layer of PDMS microchannels, the third layer of PDMS microchannels and the bottom layer of PDMS microchannels. Capillary glass tube; fix the surface acoustic wave microfluidic core-shell droplet rapid printing device on the stage of the microscope, generate core micro-droplets at the T-shaped microchannel, and cut them into cores at the end of the capillary tapered mouth Shell-shaped droplets; the surface acoustic wave acts on the straight channel, which can realize the regulation of the core droplet size inside the core-shell structure.

Description

technical field [0001] The invention relates to the technical field of microfluidics, in particular to a device and method for rapidly generating core-shell droplets based on surface acoustic wave microfluidics. Background technique [0002] Microencapsulation of biomolecules or cells is an important research tool in material synthesis, biomedical research, drug sustained release and drug delivery, among which the core step of microencapsulation is the generation of core-shell microdroplets. The traditional method for preparing core-shell double emulsion droplets usually adopts a two-step stirring method, that is, firstly adding a hydrophobic reagent to the mixed solution to obtain droplets, then placing the obtained droplet emulsion in the water phase, and then adding an emulsifier, Keep stirring to make it further into double milk core shell droplets. For example, Thompson et al. [Preparation of Pickering Double Emulsions Using BlockCopolymer Worms[J]. Langmuir, 2015, 31(...

AI Technical Summary

Problems solved by technology

However, in most core-shell microdroplet generation devices, the pressure source is usually far away from the microfluidic chip, and it needs to be connected to the microfluidic chip through a long connecting tube, and the compressibility of the fluid or channel material will cause a time delay. Further research is needed to adjust the core-shell droplet size structure on demand

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