Whole-granule wet-process mixing granulator

Abstract

The invention discloses a whole-granule wet-process mixing granulator. The granulator comprises a material cylinder, a granulating machine and a discharging device, which are sequentially arranged from top to bottom. A cylinder cover is arranged on the material cylinder; the cylinder cover is connected with an alpha-beta valve; a rotating table is arranged on one side of the material cylinder; a connecting seat is rotationally arranged on the rotating table; and the cylinder cover is hinged to a connecting base through a swing rod. The cylinder cover is provided with a positioning check ring in the circumferential direction. An abutting check ring is arranged on the peripheral wall of the material cylinder; and a limiting piece is further arranged between the positioning check ring and theabutting check ring. A closed annular groove is formed in the cylinder cover; an inflatable sealing ring is arranged in the closed annular groove; an abutting table is formed at the position, corresponding to the closed annular groove, of the opening of the material cylinder, a first cleaner is arranged in a feeding pipe, a second cleaner is arranged in the material cylinder, a third cleaner is arranged in the granulating machine, a fourth cleaner is arranged in a discharging device, and a drainage device used for draining cleaning sewage is further arranged at the bottom of the discharging device. The whole granulator has a better sealing effect, is provided with an in-place cleaning system, and completely meets the requirements of OEB4.

Description

technical field [0001] The invention relates to the technical field of powder granulation, in particular to a granulation wet mixing granulator. Background technique [0002] The whole granule wet mixing granulator is used in pharmaceutical equipment for the production of powder drugs, which improves the airtightness of the overall structure, meets the requirements of OEB4, and can avoid the leakage of toxic and highly active materials that may cause contact with the human body and cause harm. It is widely used in the pharmaceutical industry, especially antineoplastic drugs, hormone products and other highly active compounds to meet environmental, health and safety requirements. It can effectively protect operators in the development and production of solid preparations and prevent products from being cross-contaminated. In the existing whole granulation wet mixing granulator, the airtightness is insufficient. At the same time, due to the need to produce toxic and highly act...

AI Technical Summary

Problems solved by technology

In the existing whole granulation wet mixing granulator, the airtightness is insufficient. At the same time, due to the need to produce toxic and highly active materials, it is difficult to clean up, and it is easy to accumulate in the dead corner of the equipment, which is not conducive to subsequent production and reduces the use effect of the overall equipment.

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