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Product for preventing and/or treating atopic dermatitis

A technology for atopic dermatitis and products, applied in the field of microorganisms, can solve problems such as adverse reactions, poor tolerance of patients, and difficulties in the treatment of atopic dermatitis

Active Publication Date: 2020-09-25
JIANGNAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the above-mentioned drugs have relatively large adverse reactions, and most patients have concerns about hormone drugs, which not only bring great difficulties to the treatment of atopic dermatitis, but also bring great difficulties to the lives of patients. In addition, these drugs are poorly tolerated by individual patients

Method used

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  • Product for preventing and/or treating atopic dermatitis
  • Product for preventing and/or treating atopic dermatitis
  • Product for preventing and/or treating atopic dermatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Example 1: Effects of Different Lactobacillus casei on the Number of Scratchings in Atopic Dermatitis Mice

[0056] 36 6-week-old SPF (specific pathogen free) grade C57BL / 6 female mice were randomly divided into 6 groups, 6 mice in each group, and the 6 groups were: blank group, model group, positive reference group and three groups of cheese milk Bacillus experimental group, wherein, the positive reference group is the L.GG group of Lactobacillus rhamnosus GG, the three groups of Lactobacillus casei experimental groups are the CCFM1073 group of Lactobacillus casei CCFM1073, and the Lactobacillus casei 1 group. CA1 group and CA2 group fed with Lactobacillus casei 2. All mice were housed in an SPF barrier and had free access to food and water.

[0057] The experiment lasted for four weeks: the first week was the adaptation period of the mice; the second week began to gavage the mice until the end of the experiment. Lactobacillus 1, Lactobacillus casei 2 bacteria soluti...

Embodiment 2

[0060] Example 2: Effects of different Lactobacillus casei on behavioral indicators of atopic dermatitis mice

[0061] 36 6-week-old SPF (specific pathogen free) grade C57BL / 6 female mice were randomly divided into 6 groups, 6 mice in each group, and the 6 groups were: blank group, model group, positive reference group and three groups of cheese milk Bacillus experimental group, wherein, the positive reference group is the L.GG group of Lactobacillus rhamnosus GG, the three groups of Lactobacillus casei experimental groups are the CCFM1073 group of Lactobacillus casei CCFM1073, and the Lactobacillus casei 1 group. CA1 group and CA2 group fed with Lactobacillus casei 2. All mice were housed in an SPF barrier and had free access to food and water.

[0062] The experiment lasted for four weeks: the first week was the adaptation period of the mice; the second week began to gavage the mice until the end of the experiment. Lactobacillus 1, Lactobacillus casei 2 bacteria solution, ...

Embodiment 3

[0065] Embodiment 3: Effects of different Lactobacillus casei on ear thickness of atopic dermatitis mice

[0066] 36 6-week-old SPF (specific pathogen free) grade C57BL / 6 female mice were randomly divided into 6 groups, 6 mice in each group, and the 6 groups were: blank group, model group, positive reference group and three groups of cheese milk Bacillus experimental group, wherein, the positive reference group is the L.GG group of Lactobacillus rhamnosus GG, the three groups of Lactobacillus casei experimental groups are the CCFM1073 group of Lactobacillus casei CCFM1073, and the Lactobacillus casei 1 group. CA1 group and CA2 group fed with Lactobacillus casei 2. All mice were housed in an SPF barrier and had free access to food and water.

[0067] The experiment lasted for four weeks: the first week was the adaptation period of the mice; the second week began to gavage the mice until the end of the experiment. Lactobacillus 1, Lactobacillus casei 2 bacteria solution, with ...

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Abstract

The invention relates to a product for preventing and / or treating atopic dermatitis, belongs to the technical field of microorganisms and the technical field of medicines, and provides the product forpreventing and / or treating atopic dermatitis. The product contains lactobacillus casei of which the preservation No. is GDMCC No.60736. The lactobacillus casei can relieve the atopic dermatitis, andspecially reflects that the number of times of scratching of mice suffering from the atopic dermatitis can be notably reduced, the ethology characteristic of the mice suffering from the atopic dermatitis can be notably improved, the ear swelling degree of the mice suffering from the atopic dermatitis is notably improved, the skin pathology symptoms of the mice suffering from the atopic dermatitiscan be notably improved, the IgE level in serum of the mice suffering from the atopic dermatitis can be notably reduced, the IL-4 level in serum of the mice suffering from the atopic dermatitis is notably reduced, besides, the IL-10 level in the serum of the mice suffering from the atopic dermatitis can be increased, and further, the Th1 / Th2 immune reaction balance of the mice suffering from atopic dermatitis can be restored.

Description

technical field [0001] The invention relates to a product for preventing and / or treating atopic dermatitis, belonging to the technical field of microorganisms and the technical field of medicine. Background technique [0002] Atopic dermatitis (Atopic Dermatitis, AD) is a common clinical chronic, relapsing, inflammatory skin disease. The prevalence of atopic dermatitis is gradually increasing worldwide. In recent years, atopic dermatitis has affected nearly 1 / 3 of children and 3% of adults worldwide. Atopic dermatitis can cause recurrent skin itching symptoms, which will greatly affect the work and life of patients and greatly reduce the quality of life of patients. [0003] With the in-depth research of genetics and immunology, it has been found that the occurrence of atopic dermatitis is related to the joint influence of genetic factors and environmental factors. Among them, the "hygiene hypothesis" is based on the influence of environmental factors on the immune develop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/747A61P17/00A23C9/123A23C11/10A23C20/02A23L2/38A23L33/00C12N1/20C12R1/245
CPCA61K35/747A61P17/00C12N1/20A23C9/123A23C11/106A23C20/025A23L33/00A23L2/382A23V2400/125Y02A50/30
Inventor 王顺余付成丽何建新郑宋友李国平崔树茂陆文伟赵建新张灏陈卫
Owner JIANGNAN UNIV
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