Anti-depression method for fixed-point release of short-chain fatty acids by virtue of acylated starch

A technology of acylated starch and acetylated starch, which is applied in the field of acylated starch for anti-depression and anti-depression, can solve the problems of small intestinal absorption and unexplainable problems, achieve the effect of restoring normal content, improving transcription level, and achieving the effect

Inactive Publication Date: 2020-09-25
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the use of sodium salt as an antidepressant agent is flawed, it is absorbed by the small intestine, and the specific mechanism of its action cannot be explained

Method used

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  • Anti-depression method for fixed-point release of short-chain fatty acids by virtue of acylated starch
  • Anti-depression method for fixed-point release of short-chain fatty acids by virtue of acylated starch
  • Anti-depression method for fixed-point release of short-chain fatty acids by virtue of acylated starch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1: Utilizing acylated starch to achieve targeted release of short-chain fatty acids from mouse intestines

[0042] (1) Preparation of acylated starch:

[0043] High amylose corn starch and distilled water were prepared into starch milk with a mass fraction (w / w) of 40%, added to the stirring rotor, and mixed evenly on a thermal magnetic stirrer at room temperature; / L sodium hydroxide solution to adjust the starch emulsion system to pH = 8.00; add various acid anhydrides dropwise within 1.5 hours, and the amount of addition is 50% of the quality of the starch raw material. Sodium solution to maintain the pH of the reaction system = 8.00; after the dropwise addition of acid anhydride, continue to stir for 2 hours; after the reaction, adjust the pH of the system to about 5.70 with 0.50mol / L hydrochloric acid; Add 500mL of water to wash, and carry out suction filtration under 20KPa negative pressure for 5-10min; repeat the steps of washing with water until the was...

Embodiment 2

[0051] Example 2: Relief of depression by achieving targeted release of short-chain fatty acids in the intestine by acylated starch

[0052] 1. Establishment and treatment of chronic stress and depression mouse model

[0053] Based on DS=0.25, the required addition amount of various acylated starches is converted. Taking 1000g of mixed feed as an example, 150g of acylated starch with a DS of 0.25 is required. Crumble the raw feed into fine particles, add quantitative acylated starch, continue to mix, add a small amount of water several times, extrude it through a 5mL syringe, and store it in a refrigerator at -20°C. When in use, the feed is irradiated with ultraviolet Bring into the animal room barrier environment. The amount of raw feed and corresponding starch is shown in Table 1.

[0054] Table 1 Degree of substitution and dosage of acylated starch

[0055]

[0056] The 6-week-old mice were randomly divided into 7 groups according to body weight: blank control group ...

Embodiment 3

[0081] Example 3: Effects of acylated starch on depressive behavior in mice compared with short-chain fatty acids or their acid salts

[0082] 1. Short-chain fatty acid group: direct intragastric administration of short-chain fatty acids, respectively acetic acid, propionic acid, isobutyric acid, butyric acid and isovaleric acid, to intervene in depression model mice (grouping and modeling methods are the same as in Example 2, blank control group without treatment, the blank control group and the depression model group were not gavaged), the amount of gavage was equal to the molar number of short-chain fatty acids delivered by acylated starch (0.5mmol / day / only), and the mice were treated by open field experiment Behavioral tests were carried out, and the results can be seen in Figure 8 .

[0083] The latency time and moving distance of the mice in the partial acid intervention group were close to those in the depression model group, which may be due to the fact that most of ...

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Abstract

The invention discloses an anti-depression method for fixed-point release of short-chain fatty acids by virtue of acylated starch, and belongs to the anti-depression field of the acylated starch. Theacylated starch is taken as a carrier of the short-chain fatty acids and is used for simulating a physiological state to realize the fixed-point release of the short-chain fatty acids in large intestines, depression-relevant physical indexes such as depression phenotypes, ACTH, CS and 5-HT of mice are detected through animal experiments, and the acylated starch capable of realizing an anti-depression function is screened and determined through the fixed-point release of the short-chain fatty acids in intestinal tracts of the mice. The acylated starch provided by the invention is capable of relieving despondent behaviors of the despondent mice, increasing the synthesis level of neurotransmitters and relieving hypothalamus-pituitary-adrenal axis hyperfunctions caused due to the pressure. Byutilizing the anti-depression method, the fixed-point release of the short-chain fatty acids in the intestinal tracts can be realized, and the method can be taken as a diet method which targets to environments in the intestinal tracts, is relatively low in cost and is capable of relatively safely and effectively intervening depressive disorders.

Description

technical field [0001] The invention relates to an antidepressant method using acylated starch for fixed-point release of short-chain fatty acids, and belongs to the field of acylated starch for antidepressant. Background technique [0002] Depression, also known as depressive disorder, has attracted widespread attention from all walks of life in recent years because of its rapidly increasing prevalence, disability and suicide rates. Depression is a common mental disorder, often accompanied by anxiety symptoms, mainly including postpartum depression, major depressive disorder and bipolar disorder, clinically manifested as significant and persistent depression. Depression impairs social cognition, increases physical pain for patients, and also brings serious consequences such as disability and suicide, threatening social harmony and stability and economic development. The pathogenesis of depression is not yet clear, and it is generally believed to be related to the abnormali...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/718A61P25/24
CPCA23V2002/00A61K31/718A23L29/30A23L33/12A61P25/24A23V2200/322
Inventor 王刚朱慧越王琳琳田培郡邹仁英赵建新张灏陈卫
Owner JIANGNAN UNIV
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