Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Contraceptive composition with reduced cardiovascular effects

A technology for contraceptives and uses, which can be applied to medical preparations containing active ingredients, drug combinations, organic active ingredients, etc., and can solve problems such as reducing the risk of thrombosis

Pending Publication Date: 2020-09-18
ESTETRA S P R L
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These patent applications do not mention a reduction in the risk of blood clots

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Contraceptive composition with reduced cardiovascular effects
  • Contraceptive composition with reduced cardiovascular effects
  • Contraceptive composition with reduced cardiovascular effects

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0227] Research methods

[0228] A single-centre, randomized, open-label, controlled, three-arm (arm) study was performed to evaluate a combined oral contraceptive (COC) containing 15 mg estetrol (E4) and 3 mg drospirenone (DRSP) and a combination oral contraceptive (COC) containing 30 mcg ethinyl estradiol Effects of two reference COCs of ethanol (EE) and 150 mcg levonorgestrel (LNG) or 20 mcg EE and 3 mg DRSP on endocrine function, metabolic control, and hemostasis over 6 treatment cycles.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a contraceptive method with reduced cardiovascular effects, such as reduced thromboembolism risk, such as reduced venous thromboembolism (VTE) risk and reduced aorticthromboembolism (ATE) risk. The method of the invention comprises administering to a female mammal an effective amount of an estetrol component in combination with a progestogenic component. The method enjoys a favourable profile for thromboembolism compared to currently available methods which employs contraceptives from the so-called second, third or fourth generation.

Description

technical field [0001] The present invention relates to contraceptive methods with reduced cardiovascular effects, eg reduced risk of thromboembolism, such as reduced risk of venous thromboembolism (VTE) and reduced risk of aortic thromboembolism (ATE). [0002] The methods of the invention comprise administering to a female mammal an effective amount of a combination of an estetrol component and a progestin component. [0003] Further detailed herein, said method has favorable properties with respect to thromboembolism compared to currently available methods using so-called second, third and fourth generation contraceptives. Background technique [0004] The first generation of combined hormonal contraceptives (Combined Hormonal Contraceptives, CHC) included more than 50 μg doses of estrogen. But studies soon showed that this preparation was associated with an unacceptably increased risk of cardiovascular effects, depending on the dose of the estrogenic component. Subsequ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/565A61P15/18
CPCA61K31/585A61K31/565A61K9/0053A61P15/18A61K2300/00
Inventor M·约斯特G·劳辛
Owner ESTETRA S P R L
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com