Experiment method for multidrug resistant bacterial infection of burn wounds

A technology of multi-drug resistant bacteria, experimental method, applied in the medical field

Pending Publication Date: 2020-09-18
中国人民解放军32298部队
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0006] 3. Existing nano-biomaterials still have large defects in light-to-heat conversion efficiency

Method used

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  • Experiment method for multidrug resistant bacterial infection of burn wounds
  • Experiment method for multidrug resistant bacterial infection of burn wounds

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Experimental program
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Embodiment Construction

[0038] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0039] see Figure 1-2 , example:

[0040] An experimental method for multidrug-resistant bacterial infection of a burn wound, comprising the following steps:

[0041] A. Research on the targeting effect of functionalized graphene nanocomposites modified by free radical initiators on bacteria under in vivo and in vitro conditions: ① Nanomaterials bind to bacteria in vitro, ② Nanomaterials target aggregation to infection sites in vivo ;

[0042] B. Research ...

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Abstract

The invention relates to the technical field of medicines, in particular to an experiment method for multidrug resistant bacterial infection of burn wounds. The experiment method comprises the following steps of A, performing target bacteria action research on a functional graphene nanometer composite modified with a free radical initiating agent under in vivo and in vitro conditions; B, under thein vivo and in vitro conditions, performing photo-irradiation induced target antibiotic action research on the functional graphene nanometer composite modified with the free radical initiating agentunder in vivo and in vitro conditions; C, performing research of influence of the functional graphene nanometer composite modified with the free radical initiating agent on multidrug resistant bacterial infection wound healing and an action mechanism of the functional graphene nanometer composite modified with the free radical initiating agent; and D, performing research on the biological safety of the functional graphene nanometer composite modified with the free radical initiating agent. Under complex conditions, the invention provides more selections for an application of photodynamic therapy and photothermal therapy under complex conditions, provides a new treatment direction and strategy for multidrug resistant bacterial infection of burn wounds, and is favorable for further exploration of a new multi-functional nanometer platform for multidrug resistant bacteria treatment.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to an experimental method for multidrug-resistant bacterial infection of burn wounds. Background technique [0002] Controlling multidrug-resistant bacterial infections on wounds is one of the main links in the clinical treatment of severe burn patients. Traditional experimental methods involve the application of a large number of antibiotics, which will not only greatly increase bacterial drug resistance, but also seriously harm the health of patients. [0003] The existing domestic and foreign research status and trends in this area mainly focus on the use of free radicals instead of traditional experimental methods, but there are still certain problems in the research and experiment, the specific problems are as follows: [0004] 1. When treated alone, the radiation intensity required is usually higher than the skin's withstand temperature, and the resulting local high temperatu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/06C12Q1/18C12Q1/02G01N33/53A61K49/00
CPCC12Q1/06C12Q1/18G01N33/5005G01N33/53A61K49/0008
Inventor 于洵洲肖树文赵志钢王强楚妍于磊朱典勇
Owner 中国人民解放军32298部队
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